interferon

Recognition of herpesviruses by the innate immune system Paludan, Søren R.; Bowie, Andrew G.; Horan, Kristy A.; Fitzgerald, Katherine A. Advances in innate immunity over the past decade have revealed distinct classes of pattern recognition receptors (PRRs) that detect pathogens at the cell...

Link to published version here Preprint Abstract To understand the roles of acute phase viral dynamics and host immune responses in PASC, we enrolled 136 participants within 5 days of their first positive SARS-CoV-2 real-time PCR. Participants self-collected nasal specimens up to 21 times...

Recent Advances on the Innate Immune Response to Coxiella burnetii Guido Sireci, 1 Giusto Davide Badami, 1 Diana Di Liberto, 1 Valeria Blanda, 2 , * Francesca Grippi, 2 Laura Di Paola, 2Annalisa Guercio, 2 José de la Fuente, 3 , 4 and Alessandra Torina 2 Abstract Coxiella burnetii is an...

Persistent serum protein signatures define an inflammatory subcategory of long COVID Talla, Aarthi; Vasaikar, Suhas V.; Szeto, Gregory Lee; Lemos, Maria P.; Czartoski, Julie L.; MacMillan, Hugh; Moodie, Zoe; Cohen, Kristen W.; Fleming, Lamar B.; Thomson, Zachary; Okada, Lauren; Becker, Lynne A...

Major alterations to monocyte and dendritic cell subsets lasting more than 6 months after hospitalization for COVID-19 Hopkins FR, Govender M, Svanberg C, Nordgren J, Waller H, Nilsdotter-Augustinsson Å, Henningsson AJ, Hagbom M, Sjöwall J, Nyström S, Larsson M Introduction: After more than two...

"Successful elimination of bacteria in phagocytes occurs in the phago-lysosomal system, but also depends on mitochondrial pathways. Yet, how these two organelle systems communicate is largely unknown. Here we identify the lysosomal biogenesis factor transcription factor EB (TFEB) as regulator...

Premortem Skin Biopsy Assessing Microthrombi, Interferon I Antiviral and Regulatory Proteins, and Complement Deposition Correlates with Coronavirus Disease 2019 Clinical Stage Jeffrey Laurence, Gerard Nuovo, Sabrina E. Racine-Brzostek, Madhav Seshadri, Sonia Elhadad, A. Neil Crowson, J. Justin...

2022 has been an auspicious year for systemic lupus erythematosus (SLE). In February, the interferon receptor inhibitor anifrolumab became only the second targeted agent to be approved in Europe for treatment of SLE in more than six decades. A few months later, a 7-year-old Spanish girl who...

Abstract Interferon-lambda (IFN-λ) is a recently described cytokine found to be of critical importance in innate immune regulation of intestinal viruses. Endogenous IFN-λ has potent antiviral effects and has been shown to control multiple intestinal viruses and may represent a factor that...

https://www.frontiersin.org/articles/10.3389/fimmu.2021.700782/full?utm_source=F-NTF&utm_medium=EMLX&utm_campaign=PRD_FEOPS_20170000_ARTICLE Expression of CCR5 and its cognate ligands have been implicated in COVID-19 pathogenesis, consequently therapeutics directed against CCR5 are being...

Full title: Immunometabolic profiling of T cells from patients with relapsing-remitting multiple sclerosis reveals an impairment in glycolysis and mitochondrial respiration Open access, https://www.metabolismjournal.com/article/S0026-0495(17)30217-2/fulltext

Open access, https://www.biorxiv.org/content/10.1101/2020.09.22.308171v1.full-text

More Thoughts on the Interferon Study I was surprised recently when the UK press made a big splash about what was, in the end, a modest study from a team led by Carmine Pariante, a professor of psychiatry at Kings College London. I was less surprised when I realized that the Science Media...

Paywalled at https://www.sciencedirect.com/science/article/pii/S1931312818305912

Not sure whether this is really relevant, but the reference to kynurenine looked interesting. NB participants include some dodgy people, e.g. Trudie Chalder. Source: University of Essex (or Sussex?) Date: November 29, 2018 URL: http://sro.sussex.ac.uk/80506/ Persistent fatigue induced by...

https://link.springer.com/article/10.1007%2Fs10096-018-3265-z Eur J Clin Microbiol Infect Dis. 2018 May 26. doi: 10.1007/s10096-018-3265-z. [Epub ahead of print] Interferon-γ and CXCL10 responses related to complaints in patients with Q fever fatigue syndrome. Raijmakers RPH1,2, Jansen AFM3,4...