immune dysregulation

Immune exhaustion in ME/CFS and long COVID Natalie Eaton-Fitch; Penny Rudd; Teagan Er; Livia Hool; Lara Herrero; Sonya Marshall-Gradisnik Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID are debilitating multisystemic conditions sharing similarities in immune...

Abstract The pathogenesis of Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) remains unclear, though increasing evidence suggests inflammatory processes play key roles. In this study, single-cell RNA sequencing (scRNA-seq) of peripheral blood mononuclear cells (PBMCs) was used to...

Long COVID science, research and policy Al-Aly, Ziyad; Davis, Hannah; McCorkell, Lisa; Soares, Letícia; Wulf-Hanson, Sarah; Iwasaki, Akiko; Topol, Eric J. Long COVID represents the constellation of post-acute and long-term health effects caused by SARS-CoV-2 infection; it is a complex...

COVID-19 related myocardial injury is associated with immune dysregulation in symptomatic patients with cardiac MRI abnormalities Ćorović, Andrej; Zhao, Xiaohui; Huang, Yuan; Newland, Stephen; Gopalan, Deepa; Harrison, James; Giakomidi, Despina; Chen, Shanna; Yarkoni, Natalia S; Wall...

The life-saving benefit of dexamethasone in severe COVID-19 is linked to a reversal of monocyte dysregulation Rainer Knoll; Elisa T. Helbig; Kilian Dahm; Olufemi Bolaji; Frederik Hamm; Oliver Dietrich; Martina van Uelft; Sophie Müller; Lorenzo Bonaguro; Jonas Schulte-Schrepping; Lev Petrov...

n=31 Improvement of immune dysregulation in individuals with long COVID at 24-months following SARS-CoV-2 infection Abstract This study investigates the humoral and cellular immune responses and health-related quality of life measures in individuals with mild to moderate long COVID (LC)...

Pathophysiology, diagnosis, and management of neuroinflammation in covid-19 Rachel L Brown; Laura Benjamin; Michael P Lunn; Tehmina Bharucha; Michael S Zandi; Chandrashekar Hoskote; Patricia McNamara; Hadi Manji Although neurological complications of SARS-CoV-2 infection are relatively rare...

Respiratory syncytial virus directly binds miR-26, miR-27, and let-7 to de-repress gene targets through canonical and non-canonical mechanisms Sarah Ressel; Sujai Kumar; Jose Roberto Bermudez-Barrientos; Katrina Gordon; Julia Lane; Jin Wu; Cei Abreu-Goodger; Jurgen Schwarze; Amy H Buck Specific...

Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact Willian A. da Silveira; Hossein Fazelinia; Sara Brin Rosenthal; Evagelia C. Laiakis; Man S. Kim; Cem Meydan; Yared Kidane; Komal S. Rathi; Scott M. Smith; Benjamin Stear; Yue Ying...

Comparative Cohort Study of Post-Acute Covid-19 Infection with a Nested, Randomized Controlled Trial of Ivabradine for Those With Postural Orthostatic Tachycardia Syndrome (The COVIVA Study) David Saunders; Thomas B Arnold; Jason M Lavendar; Daoqin Bi; Karl Alcover; Lydia D Hellwig; Sahar T...

Immune profiling of SARS-CoV-2 infection during pregnancy reveals NK cell and γδ T cell perturbations Jennifer R. Habel; Brendon Y. Chua; Lukasz Kedzierski; Kevin J. Selva; Timon Damelang; Ebene R. Haycroft; Thi H.O. Nguyen; Hui-Fern Koay; Suellen Nicholson; Hayley A. McQuilten; Xiaoxiao Jia...

Influenza vaccination reveals sex dimorphic imprints of prior mild COVID-19 Sparks R, Lau WW, Liu C, Han KL, Vrindten KL, Sun G, Cox M, Andrews SF, Bansal N, Failla LE, Manischewitz J, Grubbs G, King LR, Koroleva G, Leimenstoll S, Snow L; OP11 Clinical Staff; Chen J, Tang J, Mukherjee A, Sellers...

Liquid biomarkers of macrophage dysregulation and circulating spike protein illustrate the biological heterogeneity in patients with post-acute sequelae of COVID-19 Christoph Schultheiss, Edith Willscher, Lisa Paschold, Cornelia Gottschick, Bianca Klee, Lidia Bosurgi, Jochen Dutzmann, Daniel...

Severe fatigue as symptom of long COVID is characterized by increased expression of inflammatory genes in monocytes, increased serum pro-inflammatory cytokines, and increased CD8+ T-lymphocytes. A putative dysregulation of the immune-brain axis, the coagulation process, and auto-inflammation to...

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the aetiologic agent of the coronavirus disease 2019 (COVID-19), is now rapidly disseminating throughout the world with 147,443,848 cases reported so far. Around 30–80% of cases (depending on COVID-19 severity) are reported...

This thread starts with discussion of the preprint. Now that the research has been published, the thread title has been changed and the abstract posted in post #13 Preprint Multi-omics provide evidence for an anti-inflammatory immune signature and metabolic alterations in patients with Long...

SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations post recovery Justin J. Frere, Randal A. Serafini, Kerri D. Pryce, Marianna Zazhytska, Kohei Oishi, Ilona Golynker, Maryline Panis, Jeffrey Zimering, Shu Horiuchi, Daisy A. Hoagland, Rasmus Møller...

Persistent Overactive Cytotoxic Immune Response in a Spanish Cohort of Individuals With Long-COVID: Identification of Diagnostic Biomarkers Miguel Galan, Lorena Vigon, Daniel Fuertes, Marıa Aranzazu Murciano-Anton, Guiomar Casado-Fernandez, Susana Domınguez-Mateos, Elena Mateos, Fernando...

Lutz L, Rohrhofer J, Zehetmayer S, Stingl M, Untersmayr E. Evaluation of Immune Dysregulation in an Austrian Patient Cohort Suffering from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Biomolecules. 2021; 11(9):1359. https://doi.org/10.3390/biom11091359 free full text...