hpa axis

  1. Hutan

    The HPA axis and the genesis of chronic fatigue syndrome, 2004, Cleare

    Abstract Many studies of patients with long-standing chronic fatigue syndrome (CFS) have found alterations to the hypothalamo-pituitary-adrenal (HPA) axis, including mild hypocortisolism, heightened negative feedback and blunted responses to challenge. However, recent prospective studies of...
  2. M

    The Link Between Empty Sella Syndrome, Fibromyalgia, and CFS: The Role of Increased Cerebrospinal Fluid Pressure (2023) Hulens et al.

    Full title: The Link Between Empty Sella Syndrome, Fibromyalgia, and Chronic Fatigue Syndrome: The Role of Increased Cerebrospinal Fluid Pressure Abstract: The etiopathogenesis of fibromyalgia (FM) and chronic fatigue syndrome (CFS) is not yet elucidated...
    • Milo
    • Thread
    • cortisol growth hormone hormone levels hpa axis intracranial hypertension prolactin thyroid hormones
    • Replies: 16
    • Forum: ME/CFS research
  3. Sly Saint

    Increases in Stress Hormone Levels in a UK Population During in the COVID-19 Pandemic: A Prospective Cohort Study 2022 Jia,Chalder et al

    Highlights • Hair cortisone significantly increased by 23% in response to the COVID-19 pandemic • Stress at the start of the pandemic associated with greater increases in cortisol • Increased cortisone more likely in people with previous mental health difficulties Abstract Background Research...
  4. Sly Saint

    An Etiological Model for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2011, Jason et al

    Abstract Kindling might represent a heuristic model for understanding the etiology of Myalgic Encephalomyelitis/chronic fatigue syndrome (ME/CFS). Kindling occurs when an organism is exposed repeatedly to an initially sub-threshold stimulus resulting in hypersensitivity and spontaneous...
  5. J

    Molecular Mechanisms of Neuroinflammation in ME/CFS and Long COVID to Sustain Disease and Promote Relapses, 2022, Tate et al.

    https://www.frontiersin.org/articles/10.3389/fneur.2022.877772/full Hypothesis Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a disease now well-documented as having arisen commonly from a viral infection, but also from other external stressors, like exposure to agricultural...
  6. Andy

    Cortisol and α-amylase awakening response in children and adolescents with functional neurological (conversion) disorder, 2022, Chung et al

    Abstract Objective: Stress system dysregulation is considered to have an important role in the aetiology of paediatric functional neurological (conversion) disorder. This study examined salivary cortisol and α-amylase awakening responses in children with functional neurological disorder to...
  7. Hutan

    Small adrenal glands in chronic fatigue syndrome: a preliminary computer tomography study, 1999, Scott et al

    Small adrenal glands in chronic fatigue syndrome: a preliminary computer tomography study Scott LV, Teh J, Reznek R, Martin A, Sohaib A, Dinan TG. https://pubmed.ncbi.nlm.nih.gov/10451910/ Abstract No inclusive or satisfactory biomedical explanation for chronic fatigue syndrome (CFS) has as...
    • Hutan
    • Thread
    • 1999 acth adrenal adrenal fatigue cortisol hpa axis me/cfs paper
    • Replies: 9
    • Forum: ME/CFS research
  8. Hutan

    Melatonin Levels in Women with Fibromyalgia and Chronic Fatigue Syndrome, 1999, Korszun et al

    An old paper Korszun, A., L. Sackett-Lundeen, E. Papadopoulos, C. Brucksch, L. Masterson, N. C. Engelberg, E. Haus, M. A. Demitrack, and L. Crofford. “Melatonin Levels in Women with Fibromyalgia and Chronic Fatigue Syndrome.” The Journal of Rheumatology 26, no. 12 (December 1999): 2675–80...
    • Hutan
    • Thread
    • 1999 cortisol fibromyalgia hpa axis me/cfs melatonin paper sleep disturbances treatment
    • Replies: 3
    • Forum: ME/CFS research
  9. Andy

    Hypothalamic-Pituitary autoimmunity and related impairment of hormone secretions in chronic fatigue syndrome, 2021, De Bellis, Montoya et al

    Abstract Context Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a severe chronic illness which reduces the quality of life. A potential role of neuroendocrine autoimmune dysfunction has been hypothesized. Objective To investigate the occurrence of anti-pituitary (APA) and...
    • Andy
    • Thread
    • 2021 acth autoantibodies cortisol endocrine growth hormone hpa axis hypothalamus me/cfs montoya pituitary
    • Replies: 48
    • Forum: ME/CFS research
  10. Kalliope

    Nature - Chronic post-COVID-19 syndrome and chronic fatigue syndrome: Is there a role for extracorporeal apheresis?, 2021, Bornstein et al

    Nature - molecular psychiatry Chronic post-COVID-19 syndrome and chronic fatigue syndrome: Is there a role for extracorporeal apheresis? - Bornstein et al Abstract As millions of patients have been infected by SARS-CoV-2 virus a vast number of individuals complain about continuing...
    • Kalliope
    • Thread
    • 2021 autoantibodies cortisol germany hpa axis hydrocortisone long covid me/cfs paper plasmapheresis
    • Replies: 17
    • Forum: ME/CFS research
  11. B

    Hypothesis: Mechanisms That Prevent Recovery in Prolonged ICU Patients Also Underlie ME/CFS: 2021, Stanculescu, Larsson and Bergquist

    https://www.frontiersin.org/articles/10.3389/fmed.2021.628029/full?utm_source=F-NTF&utm_medium=EMLX&utm_campaign=PRD_FEOPS_20170000_ARTICLE Here the hypothesis is advanced that maladaptive mechanisms that prevent recovery in some intensive care unit (ICU) patients may also underlie Myalgic...
    • Braganca
    • Thread
    • 2021 acth cortisol endocrine hpa axis hypothalamus paper pituitary
    • Replies: 53
    • Forum: ME/CFS research
  12. Sly Saint

    A Review of Hypothalamic-Pituitary-Adrenal Axis Function in Chronic Fatigue Syndrome, 2013, Tomas,Newton,Watson

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045534/ (not new but might be of interest)
    • Sly Saint
    • Thread
    • 2013 cara tomas childhood trauma cortisol endocrine hpa axis hypocortisolism julia newton me/cfs paper
    • Replies: 0
    • Forum: ME/CFS research
  13. D

    Salivary cortisol output before and after cognitive behavioural therapy for chronic fatigue syndrome, 2008, Roberts, Wessely, Chalder, Cleare

    https://www.kcl.ac.uk/ioppn/depts/pm/research/cfs/publications/assets/2009/Robertssalivary.pdf
  14. Dolphin

    Hypothalamic-Pituitary-Adrenal (HPA) Axis and Chronic Fatigue Syndrome in Older Adults: The Rehabilitation Perspectives, 2020, Ho-Yin Lai et al

    Open access peer-reviewed chapter https://www.intechopen.com/books/neuroimaging-neurobiology-multimodal-and-network-applications/hypothalamic-pituitary-adrenal-hpa-axis-and-chronic-fatigue-syndrome-in-older-adults-the-rehabilitat
  15. Barry

    Lightning Process - discussion thread

    Lightning Process- is CFS/ME psychological or physical? So, Phil fully acknowledges ME is wholly physiological ... but feels he needs to remind people how the LP can fix all that very nicely for you. Clear up some misconceptions ... :rolleyes: :sick: ETA: Is this even legal? @dave30th
  16. Andy

    Leveraging Prior Knowledge of Endocrine Immune Regulation in the Therapeutically Relevant Phenotyping of Women With CFS, 2019, Morris et al

    Paywalled at https://www.clinicaltherapeutics.com/article/S0149-2918(19)30112-2/fulltext
    • Andy
    • Thread
    • 2019 cortisol cytokines endocrine regulation hpa axis immune regulation me/cfs morris numerical modeling paper rintatolimod rituximab
    • Replies: 9
    • Forum: ME/CFS research
  17. Andy

    Review: A role for corticosteroid-binding globulin variants in stress-related disorders, 2014, Marathe & Torpey

    Not sure why this has come up as recently published but thought I'd still post it. I think this should be in biomed research but obviously it can be moved if appropriate. Paywalled at https://www.tandfonline.com/doi/abs/10.1586/eem.12.20?journalCode=iere20 Sci hub...
    • Andy
    • Thread
    • 2014 corticosteroids hpa axis marathe me/cfs metabolism paper stress torpey
    • Replies: 1
    • Forum: ME/CFS research
  18. Lidia

    The hypothalamic–neurohypophysial system regulates the hypothalamic–pituitary–adrenal axis under stress: An old concept revisited, 2006, Engelmann...

    Moderator note: This post and discussion has been moved from this thread: A compromised paraventricular nucleus within a dysfunctional hypothalamus: A novel neuroinflammatory paradigm for ME/CFS, 2018, Mackay, Tate. This is my theory of ME/CFS. The PVN is involved in physiological stress...
  19. adambeyoncelowe

    A compromised paraventricular nucleus within a dysfunctional hypothalamus: A novel neuroinflammatory paradigm for ME/CFS, 2018, Mackay, Tate.

    A compromised paraventricular nucleus within a dysfunctional hypothalamus: A novel neuroinflammatory paradigm for ME/CFS Angus MackayWarren P Tate First Published December 6, 2018 https://doi.org/10.1177/2058738418812342 Bolding in the quoted text mine for clarity.
    • adambeyoncelowe
    • Thread
    • 2018 hpa axis hypothalamus mackay me/cfs neuroinflammation paper paraventricular nucleus pet scan tate
    • Replies: 20
    • Forum: ME/CFS research
  20. P

    Gut microbiota regulates mouse behaviors through glucocorticoid receptor pathway genes in the hippocampus 2018

    Open access: https://www.nature.com/articles/s41398-018-0240-5
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