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The hypothalamic–neurohypophysial system regulates the hypothalamic–pituitary–adrenal axis under stress: An old concept revisited, 2006, Engelmann...

Discussion in 'Health News and Research unrelated to ME/CFS' started by Lidia, Dec 11, 2018.

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  1. Lidia

    Lidia Senior Member (Voting Rights)

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    Moderator note: This post and discussion has been moved from this thread:
    A compromised paraventricular nucleus within a dysfunctional hypothalamus: A novel neuroinflammatory paradigm for ME/CFS, 2018, Mackay, Tate.

    This is my theory of ME/CFS.

    The PVN is involved in physiological stress responses, as evidenced in this old study:

    The hypothalamic–neurohypophysial system regulates the hypothalamic–pituitary–adrenal axis under stress: An old concept revisited
    Mario Engelmanna, Rainer Landgrafb, Carsten T. Wotjakb
    (will find link)

    The study found that vasopressin release was the differentiating factor between psychological and physiological stress.

    My theory is that the “perpetuating psychological factors” of CFS are not psychological at all, because of the part of the brain involved.
     
    Last edited by a moderator: Dec 14, 2018
  2. MeSci

    MeSci Senior Member (Voting Rights)

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    The abstract is here:

    https://www.ncbi.nlm.nih.gov/pubmed/15589266
     
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  3. Lidia

    Lidia Senior Member (Voting Rights)

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    Here is the full paper:
    https://dacemirror.sci-hub.tw/journal-article/ebbbfdfc7a38c456b049f8639bbbdc05/engelmann2004.pdf

    It describes an experiment where rats were subjected to a psychological stressor (social defeat) and a physiological stressor (drowning) and compared their PVN response. The rats subjected to physiological stress showed increased AVP release compared with those subjected to psychological stress.

    It’s a massively cited paper.

    My theory is that ME is an immune response in this part of the brain. CFS is the aftermath of that injury.
     
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