gwas

Multi-ancestry GWAS of Long COVID identifies‬ ‭immune-related loci and etiological links to chronic fatigue‬ syndrome, fibromyalgia and depression‬ ‭ Abstract The etiology of Long COVID is poorly understood despite its estimated global burden of 65 million cases. There exists a paucity of...

Abstract The heterogeneity and complexity of symptom presentation, comorbidities and genetic factors pose challenges to the identification of biological mechanisms underlying complex diseases. Current approaches used to identify biological subtypes of major depressive disorder (MDD) mainly...

Bioinformatic analysis predicts the regulatory function of noncoding SNPs associated with Long COVID-19 syndrome Maiti, Amit K. Long or Post COVID-19 is a condition of collected symptoms persisted after recovery from COVID-19. Host genetic factors play a crucial role in developing Long...

https://www.nature.com/articles/s41588-024-01682-1 Medical Xpress: Researchers develop statistical method for genetic mapping of autoimmune diseases Wondering if something like this could help Decode ME

Genome-wide association study reveals different T cell distributions in peripheral blood of healthy individuals at high genetic risk of type 1 diabetes and long COVID Laura Deecke; Jan Homann; David Goldeck; Felix Luessi; Marijne Vandebergh; Olena Ohlei; Sarah Toepfer; Frauke Zipp; Ilja Demuth...

A signature of platelet reactivity in CBC scattergrams reveals genetic predictors of thrombotic disease risk Verdier, Hippolyte; Thomas, Patrick; Batista, Joana; Kempster, Carly; McKinney, Harriet; Gleadall, Nicholas; Danesh, John; Mumford, Andrew; Heemskerk, Johan W. M.; Ouwehand, Willem H...

Evidence of shared genetic factors in the etiology of gastrointestinal disorders and endometriosis and clinical implications for disease management Fei Yang; Yeda Wu; Richard Hockey; Jenny Doust; Gita D. Mishra; Grant W. Montgomery; Sally Mortlock In clinical practice, the co-existence of...

Absence of Association between a Long COVID and Severe COVID-19 Risk Variant of FOXP4 and Lung Cancer Luo, Yu-Si; Zhang, Ke; Cheng, Zhong-Shan No abstract. Link | PDF (Frontiers in Genetics)

Abstract Raynaud’s phenomenon (RP) is a common vasospastic disorder that causes severe pain and ulcers, but despite its high reported heritability, no causal genes have been robustly identified. We conducted a genome-wide association study including 5,147 RP cases and 439,294 controls, based...

Genome-wide Association Study of Long COVID, Lammi, Ollila et al 2023 Abstract Infections can lead to persistent or long-term symptoms and diseases such as shingles after varicella zoster, cancers after human papillomavirus, or rheumatic fever after streptococcal infections(1,2). Similarly...

Post copied from the DecodeME thread: I agree the 85% response rate is fantastic - unheard of really. Decode ME is such a brilliant study. On a related note, I found the following UCSF and University of Cambridge study on MS, published yesterday, interesting: Scientists identify first genetic...

Comorbidity genetic risk and pathways impact SARS-CoV-2 infection outcomes Jaros, Rachel K.; Fadason, Tayaza; Cameron-Smith, David; Golovina, Evgeniia; O’Sullivan, Justin M. Understanding the genetic risk and mechanisms through which SARS-CoV-2 infection outcomes and comorbidities interact to...

Abstract Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown1 to be highly efficient for discovery of genetic associations2. Despite the advanced stage of illness at presentation, we have shown that host genetics in patients who...

Virtually all the statistical methods researchers commonly use to assess genetic correlations assume that mating is random. That is, they assume that potential mating partners decide who they will have children with based on a roll of the dice. In reality, many factors likely influence who mates...

A saturated map of common genetic variants associated with human height Loic Yengo and others (multiple) Abstract Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40–50% of phenotypic variation in human height, but identifying the specific variants and...

Previous genome-wide association studies (GWASs) of stroke — the second leading cause of death worldwide — were conducted predominantly in populations of European ancestry. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European)...

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions Major depression is a debilitating psychiatric illness that is typically associated with low mood and anhedonia. Depression has a heritable component that...

Full title: No replication of previously reported association with genetic variants in the T cell receptor alpha (TRA) locus for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disease with a variety of...

Thread or here https://typefully.com/doctorveera/BZevgUj

New insights into the genetic etiology of Alzheimer’s disease and related dementias https://www.nature.com/articles/s41588-022-01024-z Abstract Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better...