gwas

Largest ME/CFS genetic study to date. Three different cohorts totaling more than 2500 patients. First Immunochip study in ME/CFS. Possible implication of TPPP genetic region https://www.sciencedirect.com/science/article/pii/S0889159122000782 TPPP plays a key role in myelination of nerve cells...

Highlights Genetics of gut motility via data on stool frequency in 167,875 individuals GWAS identifies 14 loci associated with stool frequency Candidate genes enriched in neurotransmitter signaling and enteric motor neurons Polygenic scores predict increased risk of irritable bowel syndrome...

Split from The course of the illness for ME patients in Norway, 2021, Schei and Angelsen The potential effect of sample biases on DecodeME Summary: there is some evidence that this could be a problem, but is not clear how big a problem and it may be possible to adjust for possible biases...

" Abstract Self-reported tiredness and low energy, often called fatigue, is associated with poorer physical and mental health. Twin studies have indicated that this has a heritability between 6% and 50%. In the UK Biobank sample (N = 108 976) we carried out a genome-wide association study of...

" Abstract Importance Psychotic experiences, such as hallucinations and delusions, are reported by approximately 5%-10% of the general population, though only a small proportion develop psychotic disorders such as schizophrenia. Studying the genetic aetiology of psychotic experiences in the...

https://academic.oup.com/hmg/article/doi/10.1093/hmg/ddaa169/5879704

The amazing DecodeME ME/CFS DNA project that just got funded, is holding a webinar on 6 July. Details to be announced later, presumably - this info is from emails that went out to people who registered for updates about the study.

Moderator note: Please note: at this point only people from the UK will be eligible to participate in the study. However people from anywhere, with or without ME/CFS, can register their interest in receiving updates about the study. People who register will receive information about...

Provisionally accepted opinion article in frontiers in Pediatrics - Paediatric Neurology Review of the Quality Control Checks Performed by Current Genome-Wide and Targeted-Genome Association Studies on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome by Nuno Sepulveda, Anna D. Grabowski...

I searched but couldn't find this here, which is surprising. I've also Googled and can't find details of this elsewhere...

https://www.ed.ac.uk/inflammation-research/postgraduate-training/phd-programme/research-projects The M.E. project is one of several advertised on this page. Mentions the GWAS study....

This post and the following ones have been moved from this thread. I may well start a new thread for the GWAS application (and hopefully funded study) but for the moment I'll keep updates here. Draft website goes live and feedback sought on recruitment plan. So the draft GWAS project website...

What it says on the tin! Please suggest your names here about this project. :)

Researchers propose deep trawl of DNA to help uncover the causes of ME/CFS Analysing the DNA of thousands of patients can help to uncover the genetic roots of diseases and shed light on the underlying biological mechanisms. This can reveal targets for drug development. A new and very different...

https://www.washingtonpost.com/news/national/wp/2018/06/13/feature/devastated-by-als-trying-to-save-others/?noredirect=on&utm_term=.65cc16c53602&wpisrc=nl_rainbow&wpmm=1