fatigue

Preprint Effect of Melatonin Plus Zinc Supplementation on Fatigue Perception in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial " Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex, multisystem, and...

Hypoxanthine (Hx), an intermediate metabolite of the purine metabolism pathway which is dramatically increased in blood and skeletal muscle during muscle contraction and metabolism, is characterized as a marker of exercise exhaustion. However, the physiological effects of Hx on skeletal muscle...

The researcher of the Biological Foundations of Mental Disorders group and head of the Central Sensitisation Syndrome section at the University Hospital of Santa Maria de Lleida, Lluís Rosselló, has presented the study. full article here...

https://www.medicalnewstoday.com/articles/321453#overview

" Abstract Self-reported tiredness and low energy, often called fatigue, is associated with poorer physical and mental health. Twin studies have indicated that this has a heritability between 6% and 50%. In the UK Biobank sample (N = 108 976) we carried out a genome-wide association study of...

Full title: Patients with uncomplicated COVID-19 have long-term persistent symptoms and functional impairment similar to patients with severe COVID-19: a cautionary tale during a global pandemic Open access, https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciab103/6129932

An old paper, one that I found when I was looking for papers related to physiotherapy. https://www.researchgate.net/publication/233658666_Fatigue_-_concepts_for_physiotherapy_management_and_measurement Free Abstract

• Neuropsychological and neurophysiological features of fatigue were studied in post-COVID-19 patients. • Apathy, deficits in executive functions and reduction in global cognition were found. • Abnormal shortening of cortical silent period and lack of MEP depression were demonstrated after a...

Just in case you thought we were the only ones having to put up with this crap: The middle bit sounds promising to me. The rest is the usual BS. Although it doesn't explicitly mention negative illness beliefs, I think that's implicit in the suggestion of CBT. I love how they think the fatigue...

Effect of a Tailored Activity Pacing Intervention on Fatigue and Physical Activity Behaviours in Adults with Multiple Sclerosis https://www.mdpi.com/1660-4601/18/1/17/htm Not very relevant to us but always interesting to see how similar studies are run in other diseases. I am not aware if PEM...

https://www.mdpi.com/1010-660X/56/12/726?type=check_update&version=2

preprint https://www.medrxiv.org/content/10.1101/2020.12.04.20244145v2 https://www.medrxiv.org/content/10.1101/2020.12.04.20244145v2.full.pdf

https://www.sciencedirect.com/science/article/abs/pii/S0531556520305258?dgcid=rss_sd_all

Safety and efficacy of amantadine, modafinil, and methylphenidate for fatigue in multiple sclerosis: a randomised, placebo-controlled, crossover, double-blind trial https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(20)30354-9/fulltext

I haven't tried to dig into this to try to work out whether it says something of value or not. Via: Dr. Marc-Alexander Fluks Source: Edinburgh Napier University Date: November 2020 URL...

full text: https://www.karger.com/Article/FullText/512166

https://link.springer.com/article/10.1007/s00702-020-02166-2

https://www.neurologyadvisor.com/topics/multiple-sclerosis/the-role-of-ketamine-infusion-for-patients-with-ms-related-fatigue/ Primary outcome of the study was negative. Reference Fitzgerald KC, Morris B, Soroosh A, et al. Pilot randomized active-placebo-controlled trial of low-dose ketamine...

https://lupus.bmj.com/content/5/1/e000254

https://journals.sagepub.com/doi/full/10.1177/1178646920936279