covid 19

Rampant COVID Poses New Challenges in the Fifth Year of the Pandemic “We’re still in a pandemic,” says a lead COVID official with the World Health Organization https://www.scientificamerican.com/article/rampant-covid-poses-new-challenges-in-the-fifth-year-of-the-pandemic/ (some extra line...

Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses Abstract To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and...

Over the past year there have been some social media posts relating to how COVID-19 impacts pregnancy and can cause birth defects This thread from X , pulls some research references together on it. It's not looking good . I don't know when people generally will wake up

Long-term outcomes following hospital admission for COVID-19 versus seasonal influenza: a cohort study Yan Xie; Taeyoung Choi; Ziyad Al-Aly Background Previous comparative analyses of people admitted to hospital for COVID-19 versus influenza evaluated the risk of death, hospital readmission...

Blood-brain barrier breakdown in COVID-19 ICU survivors: an MRI pilot study Wen Shi; Dengrong Jiang; Hannah Rando; Shivalika Khanduja; Zixuan Lin; Kaisha Hazel; George Pottanat; Ebony Jones; Cuimei Xu; Doris Lin; Sevil Yasar; Sung-Min Cho; Hanzhang Lu Objectives Coronavirus disease 2019...

Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics Lee, Yeji; Jeong, Michaela; Park, Jeongeun; Jung, Hyein; Lee, Hyukjin Several studies have utilized a lipid nanoparticle delivery system to enhance the effectiveness of mRNA therapeutics and...

Dynamic label-free analysis of SARS-CoV-2 infection reveals virus-induced subcellular remodeling Nell Saunders; Blandine Monel; Nadege Cayet; Lorenzo Archetti; Hugo Moreno; Alexandre Jeanne; Agathe Marguier; Timothy Wai; Olivier Schwartz; Mathieu Frechin Assessing the impact of SARS-CoV-2 on...

A global lipid map reveals host dependency factors conserved across SARS-CoV-2 variants Farley, Scotland E.; Kyle, Jennifer E.; Leier, Hans C.; Bramer, Lisa M.; Weinstein, Jules B.; Bates, Timothy A.; Lee, Joon-Yong; Metz, Thomas O.; Schultz, Carsten; Tafesse, Fikadu G. A comprehensive...

Evolutionary arms race between SARS-CoV-2 and interferon signaling via dynamic interaction with autophagy Jae Seung Lee; Mark Dittmar; Jesse Miller; Minghua Li; Kasirajan Ayyanathan; Max B Ferretti; Jesse Hulahan; Kanupriya Whig; Zienab Etwebi; Trevor Griesman; David C. Schultz; Sara Cherry...

The impact of SARS-COV-2 infection on menstruation Zhong, Xiaozhu; Lu, Keji; Liang, Weiying; Jihu, Luozi; Zeng, Anqi; Ding, Miao; Chen, Dongmei; Xie, Meiqing Recent study has demonstrated that the GnRH system in patients with post-COVID syndrome may be influenced by SARS-CoV-2. However, the...

Understanding COVID-19 progression with longitudinal peripheral blood mononuclear cell proteomics: Changes in the cellular proteome over time Giuseppe Gianini Figueirêdo Leite; Milena Karina Colo Brunialti; Paula M. Peçanha-Pietrobom; Paulo R. Abrão Ferreira; Jaquelina Sonoe Ota-Arakaki; Edecio...

Integrated longitudinal multi-omics study identifies immune programs associated with COVID-19 severity and mortality in 1152 hospitalized participants Jeremy P. Gygi; Cole Maguire; Ravi K. Patel; Pramod Shinde; Anna Konstorum; Casey P. Shannon; Leqi Xu; Annmarie Hoch; Naresh Jayavelu; IMPACC...

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can lead to postacute sequelae in multiple organ systems, but evidence is mostly limited to the first year postinfection. We built a cohort of 138,818 individuals with SARS-CoV-2 infection and 5,985,227 noninfected...

Abstract Background A few studies indicate that women infected with SARS-CoV-2 during pregnancy might have an increased risk of stillbirth. Our aim was to investigate the risk of stillbirth according to infection with SARS-CoV-2 during pregnancy also taking the variant into account. Methods We...

Now published - details here ********** Preprint Characterization of Unique Pathological Features of COVID-Associated Coagulopathy: Studies with AC70 hACE2 Transgenic Mice Highly Permissive to SARS-CoV-2 Infection Aleksandra K Drelich; Kempaiah Rayavara; Jason Hsu; Panatda Saenkham-Huntsinger...

Physical interventions to interrupt or reduce the spread of respiratory viruses Background Viral epidemics or pandemics of acute respiratory infections (ARIs) pose a global threat. Examples are influenza (H1N1) caused by the H1N1pdm09 virus in 2009, severe acute respiratory syndrome (SARS) in...

Complement factor D targeting protects endotheliopathy in organoid and monkey models of COVID-19 Highlights Longitudinal proteomics reveals aberrant complement patterns in severe COVID-19 Human PSC-vascular organoid models endotheliopathy by SARS-CoV-2 infection SARS-CoV-2 spike-ECD triggers...

Comparative study showed that children faced a 78% higher risk of new-onset conditions after they had COVID-19 Abstract Aim Children have largely been unaffected by severe COVID-19 compared to adults, but data suggest that they may have experienced new conditions after developing the disease...

Identification of new drugs to counteract anti-spike IgG-induced hyperinflammation in severe COVID-19 Abstract Previously, we and others have shown that SARS-CoV-2 spike-specific IgG antibodies play a major role in disease severity in COVID-19 by triggering macrophage hyperactivation...

COVID-19 and Long COVID: Disruption of the Neurovascular Unit, Blood-Brain Barrier, and Tight Junctions Duraisamy Kempuraj; Kristina K. Aenlle; Jessica Cohen; Annette Mathew; Dylan Isler; Rajendra P. Pangeni; Lubov Nathanson; Theoharis C. Theoharides; Nancy G. Klimas Severe acute respiratory...