Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics, 2023, Lee et al.

Immunogenicity of lipid nanoparticles and its impact on the efficacy of mRNA vaccines and therapeutics
Lee, Yeji; Jeong, Michaela; Park, Jeongeun; Jung, Hyein; Lee, Hyukjin

Several studies have utilized a lipid nanoparticle delivery system to enhance the effectiveness of mRNA therapeutics and vaccines. However, these nanoparticles are recognized as foreign materials by the body and stimulate innate immunity, which in turn impacts adaptive immunity. Therefore, it is crucial to understand the specific type of innate immune response triggered by lipid nanoparticles.

This article provides an overview of the immunological response in the body, explores how lipid nanoparticles activate the innate immune system, and examines the adverse effects and immunogenicity-related development pathways associated with these nanoparticles. Finally, we highlight and explore strategies for regulating the immunogenicity of lipid nanoparticles.

Link | PDF (Nature Experimental & Molecular Medicine)

 

Review article. Sections —

Relationship Between Innate Immunity And Adaptive Immunity
Immunogenicity of mRNA-LNP Complexes
Adverse Effects of Lipid Nanoparticles
Anaphylaxis
Autoimmune Diseases
Adjusting the Composition and Characteristics of mRNA-LNPs
Introduction of Adjuvants to LNPs
Consideration of Injection Route or Target