cortisol

Abstract Context.— Chronic fatigue syndrome (CFS) is associated with a dysregulated hypothalamic–pituitary adrenal axis and hypocortisolemia. Objective.— To evaluate the efficacy and safety of low-dose oral hydrocortisone as a treatment for CFS. Design.— A randomized, placebo-controlled...

Abstract SARS-CoV-2 infection can result in the development of a constellation of persistent sequelae following acute disease called post-acute sequelae of COVID-19 (PASC) or Long COVID. Individuals diagnosed with Long COVID frequently report unremitting fatigue, post-exertional malaise, and a...

Abstract The bio-psycho-social model highlights intra-individual and inter-individual interactions, including psychotherapy. The processing of these interactions within a person takes place, among others, in the central autonomic network (CAN). The CAN's autonomic output to the periphery can be...

Abstract Kindling might represent a heuristic model for understanding the etiology of Myalgic Encephalomyelitis/chronic fatigue syndrome (ME/CFS). Kindling occurs when an organism is exposed repeatedly to an initially sub-threshold stimulus resulting in hypersensitivity and spontaneous...

Small adrenal glands in chronic fatigue syndrome: a preliminary computer tomography study Scott LV, Teh J, Reznek R, Martin A, Sohaib A, Dinan TG. https://pubmed.ncbi.nlm.nih.gov/10451910/ Abstract No inclusive or satisfactory biomedical explanation for chronic fatigue syndrome (CFS) has as...

Abstract Symptoms of long COVID are complex and long-lasting, and endocrine dysfunction might be involved in the underlying mechanisms. In this study, to clarify the hormonal characteristics of long COVID patients, laboratory data for patients who visited the outpatient clinic for long COVID...

Abstract Objective: Stress system dysregulation is considered to have an important role in the aetiology of paediatric functional neurological (conversion) disorder. This study examined salivary cortisol and α-amylase awakening responses in children with functional neurological disorder to...

Abstract Objective. Patients suffering from chronic pain often present with multifactorial underlying conditions, sometimes without concrete pathological physical findings. Functional somatic syndromes (FSS) and somatoform disorders show a high prevalence of 8-20% and are often associated with...

Highlights Longitudinal multiomics associate PASC with autoantibodies, viremia and comorbidities Reactivation of latent viruses during initial infection may contribute to PASC Subclinical autoantibodies negatively correlate with anti-SARS-CoV-2 antibodies Gastrointestinal PASC uniquely present...

Note: cringe worthy, be warned. Abstract Stress has been demonstrated to be involved in the development of medically unexplained symptoms. A key underlying mechanism could be lower levels of cortisol, which can contribute to symptoms such as fatigue or pain. However, the literature is...

Self-soothing touch and being hugged reduce cortisol responses to stress: A randomized controlled trial on stress, physical touch, and social identity Aljoscha Dreisoernera,*, Nina M. Junkera, Wolff Schlotza,b, Julia Heimricha, Svenja Bloemekec, Beate Ditzend, Rolf van Dicka Abstract...

An old paper Korszun, A., L. Sackett-Lundeen, E. Papadopoulos, C. Brucksch, L. Masterson, N. C. Engelberg, E. Haus, M. A. Demitrack, and L. Crofford. “Melatonin Levels in Women with Fibromyalgia and Chronic Fatigue Syndrome.” The Journal of Rheumatology 26, no. 12 (December 1999): 2675–80...

Full title: Assessment of cytokines, microRNA and patient related outcome measures in conversion disorder/functional neurological disorder (CD/FND): The CANDO clinical feasibility study Highlights • It is feasible to establish and assess a cohort of CD/FND with motor symptoms, involving...

Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease usually presenting after infection. Emerging evidence supports that energy metabolism is affected in ME/CFS, but a unifying metabolic phenotype has not been firmly established. We performed global...

Abstract Context Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a severe chronic illness which reduces the quality of life. A potential role of neuroendocrine autoimmune dysfunction has been hypothesized. Objective To investigate the occurrence of anti-pituitary (APA) and...

Nature - molecular psychiatry Chronic post-COVID-19 syndrome and chronic fatigue syndrome: Is there a role for extracorporeal apheresis? - Bornstein et al Abstract As millions of patients have been infected by SARS-CoV-2 virus a vast number of individuals complain about continuing...

(Note that this is an old study from 2004) Abstract Context: There is no established pharmacological treatment for the core symptoms of chronic fatigue syndrome (CFS). Galantamine hydrobromide, an acetyl cholesterone inhibitor, has pharmacological properties that might benefit patients with...

Medscape: The Anxious History of Understanding Cortisol Came across this on Medscape today and since we've been having discussions on what "stress" is elsewhere on the forum--to say nothing of the many discussions on cortisol and ME/CFS over many years--it seemed a bit interesting to see how...

Abstract Psychosocial and socioeconomic adversity in early childhood (termed ‘social adversity’) can have lifelong detrimental effects on health and development. Physiological stress is one proposed mechanism by which social adversity ‘gets under the skin’. There is substantial research...

https://www.researchgate.net/profile/Joshua_Leisk/publication/350043016_The_true_nature_of_an_autoimmune_disease/links/604d0d31a6fdcccfee7d03be/The-true-nature-of-an-autoimmune-disease.pdf?origin=publication_detail Preprint—not peer reviewed. Abstract Here we propose a hypothetical model...