cerebrospinal fluid

  1. Nightsong

    Cerebrospinal fluid immune phenotyping reveals distinct immunotypes of myalgic encephalomyelitis/chronic fatigue syndrome, 2025, Bastos et al

    Abstract: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex heterogeneous multiorgan disease that can have severe impact on individuals' quality of life. Diagnosis of ME/CFS is based on symptom presentation, and a significant goal for the field is to establish meaningful...
    • Nightsong
    • Thread
    • cerebrospinal fluid csf matrix metalloproteinase me/cfs
    • Replies: 7
    • Forum: ME/CFS research
  2. forestglip

    Preprint Human deep sleep facilitates faster cerebrospinal fluid dynamics linked to brain oscillations for sleep homeostasis and memory, 2025, Uji et al

    Human deep sleep facilitates faster cerebrospinal fluid dynamics linked to brain oscillations for sleep homeostasis and memory Makoto Uji, Xuemei Li, An Saotome, Ryosuke Katsumata, R. Allen Waggoner, Chisato Suzuki, Kenichi Ueno, Sayaka Aritake, Masako Tamaki [Line breaks added] Abstract How...
  3. Nightsong

    Cerebrospinal fluid metabolomics, lipidomics and serine pathway dysfunction in [ME/CFS], 2025, Baraniuk

    Abstract: We proposed that cerebrospinal fluid would provide objective evidence for disrupted brain metabolism in myalgic encephalomyelitis/chronic fatigue syndroome (ME/CFS). The concept of postexertional malaise (PEM) with disabling symptom exacerbation after limited exertion that does not...
    • Nightsong
    • Thread
    • 5-methyltetrahydrofolate 5mthf baraniuk cerebrospinal fluid creatine csf exercise lipidomics lipids mass spectrometry me/cfs metabolomics myelin phospholipids serine sphingomyelin transaconitate
    • Replies: 9
    • Forum: ME/CFS research
  4. Mij

    Broad Analysis of Serum and Intrathecal Antimicrobial Antibodies in Multiple Sclerosis Underscores Unique Role of EBV, 2025, Florence Pache et al

    Abstract Background and Objectives There is a strong link between Epstein-Barr virus (EBV) and multiple sclerosis (MS), but the underlying mechanisms are unclear. Patients with MS typically have a polyspecific intrathecal production of immunoglobulin G (IgG), part of which is directed against...
  5. SNT Gatchaman

    The choroid plexus synergizes with immune cells during neuroinflammation, 2024, Xu et al.

    The choroid plexus synergizes with immune cells during neuroinflammation Huixin Xu; Peter Lotfy; Sivan Gelb; Aja Pragana; Christine Hehnly; Lillian I.J. Byer; Frederick B. Shipley; Miriam E. Zawadzki; Jin Cui; Liwen Deng; Milo Taylor; Mya Webb; Hart G.W. Lidov; Mark L. Andermann; Isaac M. Chiu...
    • SNT Gatchaman
    • Thread
    • blood brain barrier blood csf barrier cerebrospinal fluid choroid plexus immune system innate immune response macrophages monocytes neuroinflammation neutrophils
    • Replies: 1
    • Forum: Other health news and research
  6. forestglip

    Lumbar puncture, chronic fatigue syndrome and idiopathic intracranial hypertension: a cross-sectional study, 2 Dec 2013, Higgins et al

    Lumbar puncture, chronic fatigue syndrome and idiopathic intracranial hypertension: a cross-sectional study Authors: Nicholas Higgins, John Pickard, Andrew Lever Abstract Objective Unsuspected idiopathic intracranial hypertension (IIH) is found in a significant minority of patients attending...
    • forestglip
    • Thread
    • cerebrospinal fluid idiopathic intracranial hypertension lumbar puncture
    • Replies: 1
    • Forum: ME/CFS research
  7. John Mac

    Hypothesis COVID-19 and chronic fatigue syndrome: Is the worst yet to come?, Jan 2021, Wostyn

    COVID-19 and chronic fatigue syndrome: Is the worst yet to come? Peter Wostyn https://www.sciencedirect.com/science/article/pii/S0306987720333600?dgcid=rss_sd_all From the same author...
    • John Mac
    • Thread
    • anosmia cerebrospinal fluid glymphatic system intracranial hypertension long covid
    • Replies: 6
    • Forum: Long Covid research
  8. R

    Cerebrospinal fluid (CSF) proteomics

    Discussion split from discussion of an NIH webinar where there was a presentation of a forthcoming Bergquist CSF proteomics study USA: NIH National Institutes of Health news Does anyone know if CSF proteomics has been used to study other illnesses?
  9. Mij

    Cerebrospinal fluid immunoglobulins in primary progressive multiple sclerosis are pathogenic, 2023, Jamie K Wong et al

    Abstract Multiple sclerosis is clinically characterized by relapses and remissions (relapsing-remitting multiple sclerosis) that over time may evolve to a progressive course (secondary progressive multiple sclerosis) or as having a progressive course from disease onset (primary progressive...
  10. Sly Saint

    Protein biomarker profiles in serum and CSF in 158 patients with PTLDS or persistent symptoms after tick-bite /acute neuroborreliosis 2022, Nillson

    Protein biomarker profiles in serum and CSF in 158 patients with PTLDS or persistent symptoms after presumed tick-bite exposure compared to those in patients with confirmed acute neuroborreliosis Abstract Background Current diagnostics for patients with lingering symptoms categorized as...
  11. Sly Saint

    Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and fibromyalgia are indistinguishable by their cerebrospinal fluid proteomes 2022, Schutzer et al

    Steven E Schutzer, Tao Liu, Chia-Feng Tsai, Vladislav A Petyuk, Athena Schepmoes, Yi-Ting Wang, Karl Weitz, Jonas Bergquist, Richard Smith, Benjamin Natelson preprint Abstract Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and fibromyalgia have overlapping neurologic symptoms...
    • Sly Saint
    • Thread
    • bergquist cerebrospinal fluid csf fibromyalgia me/cfs proteomics schutzer
    • Replies: 14
    • Forum: ME/CFS research
  12. cassava7

    Tryptophan metabolites in cerebrospinal fluid of ME/CFS patients, Maccallini, 2022

    I present here a comparison between the levels of tryptophan (Trp), kynurenine (Kyn), serotonin (Ser), Kyn/Trp, and Ser/Trp in cerebrospinal fluid of 44 ME/CFS patients vs 21 sedentary controls. Raw data were retrieved from (Baraniuk JN et al. 2021). Stratification by sex has been included in...
    • cassava7
    • Thread
    • cerebrospinal fluid kynurenine metabolites metabolomics tryptophan
    • Replies: 5
    • Forum: ME/CFS research
  13. SNT Gatchaman

    Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels, 2022, Mazzitelli et al

    Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels Jose A. Mazzitelli, Leon C. D. Smyth, Kevin A. Cross, Taitea Dykstra, Jerry Sun, Siling Du, Tornike Mamuladze, Igor Smirnov, Justin Rustenhoven and Jonathan Kipnis It remains unclear how immune cells...
  14. Wyva

    Risk factors and abnormal cerebrospinal fluid associate with cognitive symptoms after mild COVID-19, 2022, Apple et al

    Abstract Cognitive post-acute sequelae of SARS-CoV-2 (PASC) can occur after mild COVID-19. Detailed clinical characterizations may inform pathogenesis. We evaluated 22 adults reporting cognitive PASC and 10 not reporting cognitive symptoms after mild SARS-CoV-2 infection through structured...
    • Wyva
    • Thread
    • 2022 cerebrospinal fluid cognitive dysfunction covid-19 long covid paper risk factors study
    • Replies: 5
    • Forum: Long Covid research
  15. Mij

    Bacterial neurotoxic metabolites in multiple sclerosis cerebrospinal fluid and plasma, 2021, Achilles Ntranos

    Abstract The identification of intestinal dysbiosis in patients with neurological and psychiatric disorders has highlighted the importance of gut-brain communication and yet, the question regarding the identity of the components responsible for this cross talk remains open. We previously...
  16. Colin

    Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep, 2019, Fultz et al

    Nina E. Fultz, Giorgio Bonmassar, Kawin Setsompop, Robert A. Stickgold, Bruce R. Rosen, Jonathan R. Polimeni, Laura D. Lewis. Abstract Sleep is essential for both cognition and maintenance of healthy brain function. Slow waves in neural activity contribute to memory consolidation, whereas...
  17. Hoopoe

    Informatics Inference of Exercise-Induced Modulation of Brain Pathways Based on Cerebrospinal Fluid Micro-RNAs in ME/CFS, 2020, Narayan et al

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703497/
    • Hoopoe
    • Thread
    • 2020 baraniuk cerebrospinal fluid micro-rna narayan paper pem
    • Replies: 21
    • Forum: ME/CFS research
  18. J

    Serological and metagenomic interrogation of cerebrospinal fluid implicates enteroviruses 2 in pediatric acute flaccid myelitis (2019) Schubert et al

    Preprint made available here. https://www.biorxiv.org/content/biorxiv/early/2019/06/10/666230.full.pdf
  19. Andy

    The putative glymphatic signature of chronic fatigue syndrome: A new view on the disease pathogenesis and therapy, 2018, Wostyn et al

    Paywalled at https://www.medical-hypotheses.com/article/S0306-9877(18)30548-6/fulltext
    • Andy
    • Thread
    • cerebrospinal fluid glymphatic system me/cfs pathogenesis
    • Replies: 31
    • Forum: ME/CFS research
  20. Andy

    Spinal fluid evacuation may provide temporary relief for patients with unexplained widespread pain and fibromyalgia, 2018, Hulens et al

    Paywalled at https://www.medical-hypotheses.com/article/S0306-9877(18)30428-6/fulltext
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