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Serological and metagenomic interrogation of cerebrospinal fluid implicates enteroviruses 2 in pediatric acute flaccid myelitis (2019) Schubert et al

Discussion in 'Health News and Research unrelated to ME/CFS' started by JohnTheJack, Jun 14, 2019.

  1. JohnTheJack

    JohnTheJack Moderator Staff Member

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    Preprint made available here.

    https://www.biorxiv.org/content/biorxiv/early/2019/06/10/666230.full.pdf

     
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  2. Andy

    Andy Committee Member & Outreach

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    I think this is now published as
    Paywall, https://www.nature.com/articles/s41591-019-0613-1
    Not currently available via Scihub

    Article about this and another recent study, https://www.sciencemag.org/news/2019/10/evidence-links-poliolike-disease-children-common-type-virus
     
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  3. InitialConditions

    InitialConditions Senior Member (Voting Rights)

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  4. InitialConditions

    InitialConditions Senior Member (Voting Rights)

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    Are there studies of searches for enteroviruses in the CSF of M.E. patients?
     
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  5. Sarah94

    Sarah94 Senior Member (Voting Rights)

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  6. Sarah94

    Sarah94 Senior Member (Voting Rights)

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    Do these findings make it more likely that an enterovirus may be involved in ME too?
     
  7. Jonathan Edwards

    Jonathan Edwards Senior Member (Voting Rights)

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    I don't think so. If anything they emphasise how clinically different ME is from enteroviral infections.
     
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  8. Sarah94

    Sarah94 Senior Member (Voting Rights)

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    Thanks, can you expand on that please?
     
  9. Jonathan Edwards

    Jonathan Edwards Senior Member (Voting Rights)

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    Enteroviral infections like polio and this one produce permanent local nerve cell damage with corresponding clinical signs from a one off episode. ME does not produce local nerve cell damage as far as we know and the illness is chronic and fluctuating. There really is no similarity as far as I can see.

    I think the whole discussion about ME and enteroviruses comes from the confusion raised by Acheson and others who muddled an acute epidemic that might or might not have been associated with focal neurological lesions and a chronic illness that followed in some case. Even if we think ME in recent times is in some cases precipitated by viral infections the acute illness and ME are completely different problems.
     

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