brain imaging

Review of Neuroimaging Methods in ME/CFS Thapaliya, Kiran; Inderyas, Maira; Barnden, Leighton The brain is the most complex organ in the human body, and is involved in memory, speech, and movement, as well as regulating the functions of many other organs within the body. Various imaging...

Hippocampal subfield volume alterations and associations with severity measures in long COVID and ME/CFS: A 7T MRI study Kiran Thapaliya; Sonya Marshall-Gradisnik; Natalie Eaton-Fitch; Markus Barth; Maira Inderyas; Leighton Barnden Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue...

Neuroimaging markers of cognitive fatigue in individuals with post-acute sequelae of SARS-CoV-2 infection Niemczak; Ford; Roth; Leigh; Parsonnet; Martin; Soule; Haron; Buckey Jr.; Wylie Persistent cognitive fatigue (CF) is the most reported symptom in Post-Acute Sequelae of SARS-CoV-2 Infection...

Frontal-striatal glucose metabolism and fatigue in patients with multiple sclerosis, long COVID, and COVID-19 recovered controls Rudroff, Thorsten This study compared brain glucose metabolism using FDG-PET in the caudate nucleus, putamen, globus pallidus, thalamus, and dorsolateral prefrontal...

Free full text: https://www.tandfonline.com/doi/full/10.1080/21641846.2024.2367921 Case Report White-matter changes associated with a synergetic treatment for myalgic encephalomyelitis/chronic fatigue syndrome Abdalla Z. Mohamed Jorge do Campo Peter Del Fante Richard Kwiatek Vince D. Calhoun &...

Metabolic changes assessed by 1H MR spectroscopy in the corpus callosum of post-COVID patients Pajuelo, Dita; Dezortova, Monika; Hajek, Milan; Ibrahimova, Marketa; Ibrahim, Ibrahim OBJECTIVES Many patients with long COVID experience neurological and psychological symptoms. Signal abnormalities...

Persistent brain metabolic impairment in long COVID patients with persistent clinical symptoms: a nine-month follow-up 18FFDG-PET study Horowitz, Tatiana; Dudouet, Pierre; Campion, Jacques-Yves; Kaphan, Elsa; Radulesco, Thomas; Gonzalez, Sandra; Cammilleri, Serge; Ménard, Amélie; Guedj, Eric...

Another PET TSPO neuroimaging study suggesting neuroinflammation involving microglia, this time in PTLDS: https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-018-1381-4

Structural and functional brain alterations in patients with myasthenia gravis Klaus, Benita; Müller, Patrick; van Wickeren, Nora; Dordevic, Milos; Schmicker, Marlen; Zdunczyk, Yael; Brigadski, Tanja; Leßmann, Volkmar; Vielhaber, Stefan; Schreiber, Stefanie; Müller, Notger G. Myasthenia gravis...

Highlights Neuroinflammation is the most convincing hypothesis for ME/CFS pathophysiology, explaining its multifaceted symptoms and pathological features. Across various neuroimaging techniques, including MRI, MRS, PET, and EEG, the frontal cortex was the most frequently observed region. Our...

Published version linked in this later post here Preprint Abstract The COVID-19 pandemic caused by SARS-CoV-2 has triggered a consequential public health crisis of post-acute sequelae of COVID-19 (PASC), sometimes referred to as long COVID. The mechanisms of the heterogeneous persistent...

Objective Fibromyalgia (FM) is characterized by pervasive pain-related symptomatology and high levels of negative affect. Mind-body treatments such as cognitive-behavioral therapy (CBT) appear to foster improvement in FM via reductions in pain-related catastrophizing, a set of negative...

No evidence for the association between COVID-19 and neuroinflammation: A diffusion basis spectrum imaging study. Wei Zhang; Aaron J Gorelik; Qing Wang; Sara A Norton; Tamara Hershey; Janine D Bijsterbosch; Ryan Bogdan COVID continues to be a major international public health concern, the...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418342/ Abstract Neuroimaging has been pivotal in identifying and reframing our understanding of functional movement disorders. If accessible, it compensates for the limitations of the clinical exam and is especially useful where there is overlap of...

A couple of recent posts, in Increase in prefrontal cortical volume following cognitive behavioural therapy in patients with CFS, 2008, de Lange et al (that one made a big deal of a 0.7% change in grey matter volume in people with ME/CFS, supposedly achieved by CBT) Hypothalamus volumes in...

https://n.neurology.org/content/early/2023/04/26/WNL.0000000000207309 Background and Objectives: Post-COVID condition (PCC) is common and often involves neuropsychiatric symptoms. This study aimed to use blood-oxygenation-level-dependent functional MRI (BOLD-fMRI) to assess whether...

Measuring extracellular human brain pH and amino acid metabolism with hyperpolarized [1-13C]pyruvate Alixander S Khan; Mary A McLean; Joshua D Kaggie; Ines Horvat-Menih; Tomasz Matys; Rolf F Schulte; Matthew Locke; Ashley Grimmer; Pascal Wodtke; Elizabeth Latimer; Amy Frary; Martin J Graves...

Now published - link here Preprint Rapid whole-brain high-resolution myelin water fraction mapping from extremely under-sampled magnetic resonance imaging data using deep neural network Zhaoyuan Gong, Nikkita Khattar, Matthew Kiely, Curtis Triebswetter, Mustapha Bouhrara Changes in myelination...

Preprint Blood-brain barrier disruption in Long COVID-associated cognitive impairment Chris Greene, Ruairi Connolly, Declan Brennan, Aoife Laffan, Eoin O'Keeffe, Lilia Zaporojan, Emma Connolly, Cliona Ni Cheallaigh, Niall Conlon, Colin Doherty, Matthew Campbell Vascular disruption has been...

Abstract Objective COVID-19 (SARS-CoV-2) has been associated with neurological sequelae even in those patients with mild respiratory symptoms. Patients experiencing cognitive symptoms such as “brain fog” and other neurologic sequelae for 8 or more weeks define “long haulers”. There is limited...