brain imaging

Abstract from 2021 preprint There is strong evidence for brain-related pathologies in COVID-19, some of which could be a consequence of viral neurotropism. The vast majority of brain imaging studies so far have focused on qualitative, gross pathology of moderate to severe cases, often carried...

Abstract During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, neurological symptoms increasingly moved into the focus of interest. In this prospective cohort study, we assessed neurological and cognitive symptoms in hospitalized coronavirus disease-19 (COVID-19)...

Performed detailed molecular and spatial analysis of the COVID-19 brain immune response Pathognomonic microglial nodules and T cell infiltration are present in COVID-19 brains Altered microglia-T cell interactions correlate with systemic measures of inflammation Vascular leakage is linked with...

Neurostructural and Neurophysiological Correlates of Multiple Sclerosis Physical Fatigue: Systematic Review and Meta-Analysis of Cross-Sectional Studies Paula M. Ellison, Stuart Goodall, Niamh Kennedy, Helen Dawes, Allan Clark, Valerie Pomeroy, Martin Duddy, Mark R. Baker & John M. Saxton...

Per Kristian Eide, Vegard Vinje, Are Hugo Pripp, Kent-Andre Mardal, Geir Ringstad Brain, Volume 144, Issue 3, March 2021, Pages 863–874, https://doi.org/10.1093/brain/awaa443 Published: 23 March 2021 It remains an enigma why human beings spend one-third of their life asleep. Experimental...

(Paragraphed for clarity) Although post-acute cognitive dysfunction and neuroimaging abnormalities have been reported after hospital discharge in patients recovered from COVID-19, little is known about persistent, long-term alterations in people without hospitalization. We conducted a...

https://link.springer.com/article/10.1007/s00259-021-05215-4

https://www.jns-journal.com/article/S0022-510X(21)00019-8/fulltext

An interesting read given the past TSPO-PET neuroinflammation studies on ME using first generation [11C]PK-11195 and now more recently second generation [11C]DPA-713, the pros/cons and limitations of these radioligands, and the development of novel third generation ligands. Recent Developments...

Couldn’t find the abstract.

I have just seen this new paper on Twitter. A timely reminder that imaging and the subsequent analysis is not an exact science. https://www.biorxiv.org/content/10.1101/843193v1 Abstract Data analysis workflows in many scientific domains have become increasingly complex and flexible. To assess...

https://www.sciencedirect.com/science/article/pii/S2213158220302035

Free full text: https://www.annalsmedres.org/item/1688-increased-intracranial-pressure-in-migraine-neuroimaging-study-on-a-cohort-of-migraineurs-p-1554-60.html

Full title: Machine Learning Detects Pattern of Differences in Functional Magnetic Resonance Imaging (fMRI) Data between Chronic Fatigue Syndrome (CFS) and Gulf War Illness (GWI) Open access, https://www.mdpi.com/2076-3425/10/7/456/htm This is a follow-on from A Machine Learning Approach to...

Full title: Coexistence of cerebral hypometabolism and neuroinflammation in the thalamo-limbic-brainstem region in young women with functional somatic syndrome Note: Due to vague selection criteria this may, or may not, be an investigation into ME. Open access...

To paraphrase, "We've found changes in the brains of people with "FSS", this then proves that "FSS" is valid category! It certainly doesn't mean that there is an actual disease mechanism at work, oh no!" :banghead: Open access...

Full title: Cerebral blood flow is reduced in ME/CFS during head-up tilt testing even in the absence of hypotension or tachycardia: a quantitative, controlled study using Doppler echography https://www.sciencedirect.com/science/article/pii/S2467981X20300044 Patients were classified as...

Full Title: A Machine Learning Approach to the Differentiation of Functional Magnetic Resonance Imaging Data of Chronic Fatigue Syndrome (CFS) From a Sedentary Control. https://www.frontiersin.org/articles/10.3389/fncom.2020.00002/full

Google publishes largest ever high-resolution map of brain connectivity (Jan 2, 2020) by James Vincent - The Verge It’s a fruit fly brain, but it’s still impressive .