b cells

  1. leokitten

    Integrated analysis of plasma and single immune cells uncovers metabolic changes in individuals with COVID-19, 2021, Lee et al

    Pure speculation but maybe this line of research or the methods used in the paper to understand immune cell metabolic reprogramming via single-cell multiomics could eventually help explain whatever possible cellular metabolic changes that are triggered and persist in Long COVID and ME/CFS…...
  2. Andy

    Latent gammaherpesvirus exacerbates arthritis through modification of age-associated B cells, 2021, Mouat et al

    In mice. Abstract Epstein-Barr virus (EBV) infection is associated with rheumatoid arthritis (RA) in adults, though the nature of the relationship remains unknown. Herein, we have examined the contribution of viral infection to the severity of arthritis in mice. We have provided the first...
  3. cassava7

    Preprint: Vaccination boosts protective responses and counters SARS-CoV-2-induced pathogenic memory B cells, Mishra et al, 2021

    Given the rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the recent implementation of SARS-CoV-2 vaccination, we have much to learn about the duration of immune protection and the interface between the immune responses to infection and to vaccination...
  4. Andy

    Skewing of the B cell receptor repertoire in myalgic encephalomyelitis/chronic fatigue syndrome, 2021, Sato et al

    Highlights • ME/CFS is characterized by skewed B cell receptor gene usage. • Upregulation of specific IGHV genes correlated to infection-related episodes at onset. • Plasmablasts of ME/CFS patients upregulated interferon response genes. • B cell receptor repertoire analysis can provide a useful...
    • Andy
    • Thread
    • 2021 autoimmunity b cell receptor b cells biomarker corticosteroids genetics hydrocortisone ivig japan me/cfs paper sato takashi yamamura wakiro sato
    • Replies: 26
    • Forum: ME/CFS research
  5. Marky

    The possibility of autoimmunity or auto-reactivity in ME/CFS

    This thread was split from Open Medicine Foundation (OMF) News I thought we could not conclude autoimmunity is likely out of the picture as long as we dont know how to target long lived plasma cells? I mean b-cells dont really matter at that point if im not mistanken, as the autoimmune plasma...
  6. Andy

    Plasma proteomic profiling suggests an association between antigen driven clonal B cell expansion and ME/CFS, 2020, Lipkin et al

    Open access, https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0236148
    • Andy
    • Thread
    • 2020 b cell receptor b cells camp kinase inhibitor lipkin lymphoma me/cfs paper proteomics
    • Replies: 31
    • Forum: ME/CFS research
  7. R

    Autoimmunity-Related Risk Variants in PTPN22 and CTLA4 Are Associated With ME/CFS With Infectious Onset (2020) Scheibenbogen et al.

    https://www.frontiersin.org/articles/10.3389/fimmu.2020.00578/full Excerpt: In conclusion, our study shows that the PTPN22 rs2476601 and CTLA4 rs3087243 autoimmunity risk variants are more frequent in patients with ITO ME/CFS. This finding provides further evidence that there is a genetic...
    • Ron
    • Thread
    • 2020 autoimmunity b cells genetics me/cfs paper pathogenesis scheibenbogen steiner t cells
    • Replies: 10
    • Forum: ME/CFS research
  8. Sly Saint

    BIOMARKER FOR MYALGIC ENCEPHALOMYELITIS/CHRONIC FATIGUE SYNDROME (ME/CFS) - Yamamoto et al 27 Feb 2020

    https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2020040210&tab=PCTBIBLIO (main paper in japanese)
    • Sly Saint
    • Thread
    • 2020 b cells biomarker iggr me/cfs paper t cells yamamoto
    • Replies: 6
    • Forum: ME/CFS research
  9. M

    B-Lymphocyte Depletion in Patients With ME/cfs: A Randomized, Double-Blind, Placebo-Controlled Trial (2019) Fluge et al

    B-Lymphocyte Depletion in Patients With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial https://annals.org/aim/article-abstract/2729813/b-lymphocyte-depletion-patients-myalgic-encephalomyelitis-chronic-fatigue-syndrome-randomized...
    • Milo
    • Thread
    • 2019 b cells fluge me/cfs mella paper rct rituximab
    • Replies: 82
    • Forum: ME/CFS research
  10. Snowdrop

    Deficient EBV-Specific B and T-cell response in patients with CFS, 2014, Loebel et al.

    Have no idea of what any of this means. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0085387 Hope it's of some interest.
    • Snowdrop
    • Thread
    • 2014 b cells ebv immunology loebel me/cfs paper t cells
    • Replies: 1
    • Forum: ME/CFS research
  11. Webdog

    Memory B Cells Activate Brain-Homing, Autoreactive CD4+ T Cells in Multiple Sclerosis (2018) Jelcic et al

    Study: Memory B Cells Activate Brain-Homing, Autoreactive CD4+ T Cells in Multiple Sclerosis https://www.sciencedirect.com/science/article/pii/S0092867418310274 News Article: How B-cells Work to Promote T-cell Attacks on Myelin That Lead to MS Detailed in Study...
  12. Indigophoton

    Bad antibodies made good: The immune system's secret weapon uncovered

    The article, https://medicalxpress.com/news/2018-04-bad-antibodies-good-immune-secret.amp The paper, http://science.sciencemag.org/content/360/6385/223
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