Looking forward
The opportunities for further clinical research into autonomic medicine are too numerous to list. However, by pointing to a number of strategic areas, I hope to stimulate thought and catalyze ideas for potential research projects:
• Well-designed epidemiologic studies are needed...
Full title:
Implantable neurostimulators for neurogenic orthostatic hypotension: the wave of the future? and Other updates on recent autonomic research, 2022, Mitchell G. Miglis et al
Multiple system atrophy (MSA) is the most aggressive neurodegenerative disease of alpha-synuclein deposition...
Abstract
Background and Objectives Various peripheral neuropathies, particularly those with sensory and autonomic dysfunction may occur during or shortly after acute COVID-19 illnesses. These appear most likely to reflect immune dysregulation. If similar manifestations can occur with the...
Abstract
Background: Patients with PASC often report symptoms of orthostatic intolerance and autonomic dysfunction. Numerous case reports link Postural Orthostatic Tachycardia Syndrome (POTS) to PASC. No prospective analysis has been performed.
Objective: We performed head-up tilt table (HUTT)...
New findings suggest a link between rosacea severity and poor sleep. The study highlights the role that obstructive sleep apnea plays: OSA may be accompanied by autonomic system activation and catecholamine release, which can aggravate rosacea...
Abstract
In normal subjects natriuresis is tightly coupled to dietary salt ingestion to maintain sodium balance. Likewise, blood pressure remains unchanged over a wide range of salt intake because of pressure natriuresis, whereby an increase in blood pressure stimulates renal sodium excretion...
Characterization and Intervention Studies in Patients with Postural Orthostatic Tachycardia Syndrome and Inappropriate Sinus Tachycardia Associated with Post-Acute COVID-19 Syndrome
Principal Investigator: Dr. Marcus Stahlberg [Ståhlberg], Karolinska University, Sweden
"The overall purpose of...
Introduction
SARS-CoV-2 infection which causes the disease COVID-19 is most known for its severe respiratory complications. However, a variety of extrapulmonary effects have since been described, with cardiovascular complications being amongst the most common[1]. Those who recover from the acute...
Abstract
Background
The Composite Autonomic Symptom Score 31 (COMPASS 31) is a validated, 31-item self-assessment questionnaire assessing autonomic symptoms in six domains, orthostatic intolerance, vasomotor, secretomotor, gastrointestinal, bladder, and pupillomotor function. So far, there is no...
Cortical autonomic network connectivity predicts symptoms in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
IntJPsychophysiol 2021 Oct 15; Online ahead of print.
Authors.
Mark A Zinn, Leonard A Jason.
Abstract
Myalgic encephalomyelitis and chronic fatigue syndrome (ME/CFS)...
Abstract
The autonomic nervous system (ANS) can be affected by COVID-19, and dysautonomia may be a possible complication in post-COVID individuals. Orthostatic hypotension (OH) and postural tachycardia syndrome (POTS) have been suggested to be common after SARS-CoV-2 infection, but other...
I was browsing https://thedysautonomiaproject.org/ and I found this free e-book, "Principles of Autonomic Medicine" by David S. Goldstein :
https://thedysautonomiaproject.org/wp-content/uploads/2020/06/Principles-of-Autonomic-Medicine-v.-3.0.pdf
I have not read this book. But I did skim the...
Post-acute COVID-19 syndrome (PACS) is a collection of persistent and debilitating symptoms lasting weeks to months after acute COVID-19 infection, with fatigue most commonly reported. There is controversy surrounding the role of exercise programs for this condition, due to concerns over the...
Abstract
Medically unexplained symptoms (MUS) are persistent bodily symptoms without known pathology. An unofficial term has recently emerged in Taiwan to accommodate MUS: autonomic imbalance (AI). AI literally refers to disturbances of the autonomic nervous system (ANS) that innervates vital...
Full title:
Association between quadrivalent human papillomavirus vaccination and selected syndromes with autonomic dysfunction in Danish females: population based, self-controlled, case series analysis
My bolding
https://www.bmj.com/content/370/bmj.m2930.full.print
Doug Lindsay was bedridden for 11 years with a mysterious illness nobody could figure out, so the college dropout figured it out for himself.
This is an amazing story
https://www.physiology.org/doi/abs/10.1152/ajpheart.00680.2018?journalCode=ajpheart
This isn't ME/CFS research but it's not unrelated either, so I thought this should be in the ME/CFS research section.
Full paper (PDF file), https://link.springer.com/epdf/10.1007/s10286-018-00586-5?shared_access_token=STPXS4PtJZOInVSXh8x-Mfe4RwlQNchNByi7wbcMAY660rig95e8st82z-CMxT4KiCk81BpD7DOoNq3KMVlYwM6FCVf_FXKtfFM1z-YvJJbjMgP9QCLqADOEFlJpB88Elu-TN36S3zHCJJbtNRbx7FEiObmkUmlXDKOql6z1yPE%3D
also paywalled at...
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