That's kind of like asking what is the best flavour of ice cream, there are many different, and conflicting, answers.
This sort of question has been asked before, here are a couple of other threads on the topic that will offer various opinions to hopefully help you make a decision.
Without commenting on 'what's the best organisation' - orgs each set the own priorities and it's a matter whether each of us as individuals share those priorities or not - the two UK orgs to consistently put charitable funds into biomed research are:
Incase anyone stumbles upon this in 2024 or later, the ME Association has had significant controversies recently and I wouldn’t recommend donating at this time.
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