Use of sildenafil (viagra) to alter fatigue, functional status and impaired cerebral blood flow in ... CFS, 2020, Friedman (Pfizer)

I agree, this study could have been really interesting.

Measures of 2 day CPET and peripheral blood flow would have been interesting, though that wouldn't have helped the recruitment figures very much.

 

I actually tried Cialis once, because me and another with ME who become much better with alcohol hypophesized that the increased blood flow not only to the penis, but lungs, might improve symptoms.

Turned out it only further improved function locally however

And gave me a headache

Edit: I also tried Nitroglycerine (dilates blood vessels systemically), which gave me an even worse pounding headache

 

I feel some temporary relief taking Niacin (a vasodilator). Niacin is also hypothesized to be involved in The Metabolic Trap Hypothesis. It's made from NAD, if I remember correctly, which in turn is made from kynurenine, which the models predict is what's missing.

 

Hardly

 

That's interesting, I've found I have the exact same thing. Do you know if there's been any research on it? I've only been able to find reference to alcohol intolerance in the literature so far.​

 

Welcome to the gang!
Dont think there has been..
I contacted Haukeland about it and asked if they would like to investigate, they were aware of the situation, but not something they prioritize obviously since were a small sub group

 

In some situations alcohol can increase my capabilities, temporarily, so it's not unheard of, by me.

I have always assumed that this is due to it maybe having an effect on blood flow in my brain.

The downside is generally quite unfunny, but I have occasionally been quite surprised by how rapid the improvement has been when I am barely able to stand up (due to having been expected to do too much socially) after even a small amount of alcohol (generally beer flavour).

I do not as a rule drink, due to the downsides.

 

Who says anything about hiding symptoms?

Viagra has a major effect on me. I experience less pain and fatigue. Not sure if I would be much better if I took it every day, but when I have done too much or need to do more than I able to, then taking Viagra helps a lot. I get some of the same effect after drinking alcohol.

I am mostly houseridden. ME accoridng to CDC/ICC. Very much pain, especially in my legs.

 

Sorry to hear that the ME is so bad these days @deleder2k sending hugs.