Use of antidepressants for/with ME/CFS?

[Turtle]

Lipid storage myopathy associated with sertraline is an acquired mitochondrial disorder with respiratory chain deficiency, 2024, Hedberg-Oldfors+
Looks as though sertraline is associated with a muscle weakness disorder.

Acquired ischemic mitochondrial myopathy was a term used by Schiebenbogen\Wirth 2024, could there be a connection with ME/CFS?

 

[Jesse]

I've been on Lexapro for 2 years now. Doesn't help with fatigue but helps me a lot with mood and just makes being so sick more manageable.

 

[Snow Leopard]

Yes it seems tricyclics are one of those things they throw at the wall to see if they stick

I cannot stand tricyclics at all, too many side effects even at low doses.

SSRIs have shown to be largely ineffective for depression in double blindied studies of ME/CFS patients.

MAOIs seem to be the ugly duckling that doctors are reluctant to prescribe, yet they have the best evidence base.