USA: Mount Sinai PACS clinic and Dr David Putrino

Jonathan Edwards said:
Well if he 'shared early results' it wasn't triple blind, was it?

I can guarantee that a low level magnetic field will have no useful effect on neuroinflammation that isn't there. This is a situation where the mind has to be kept open enough for the brain to fall out.
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I share your skepticism on the therapy but I assume it means they have unblinded and are writing/have written the paper?

Or am I missing something?
 


“Hi! We are slated for first-in-human mitochondrial transplantation this year. AND my announcement about the MMT therapy was 100% home-based. I’m excited to provide all sorts of options to all patients. My role is to build functional, actionable toolkits, not to sell magic bullets”

Putrino doing mitochondrial transplants—he is a man of many skills!

Who is we?
 
Jaybee00 said:


“Hi! We are slated for first-in-human mitochondrial transplantation this year. AND my announcement about the MMT therapy was 100% home-based. I’m excited to provide all sorts of options to all patients. My role is to build functional, actionable toolkits, not to sell magic bullets”

Putrino doing mitochondrial transplants—he is a man of many skills!

Who is we?
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Why is it that people who flog poorly evidenced treatments always go on about there not being magic bullets, like that makes their poorly evidenced treatment more appealing?
 
Felis Catus said:
Treatment studies we've got from Putrino:
- MeoHealth breathing programme
- pacing using Visible
- MMT using a Fareon device for neuroinflammation
- Boluoke lumbrokinase supplement for microclots

I think he's missing acupuncture.
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He was also part of one of the Paxlovid trials with negative results and is running a Rapamycin study in LC and ran a VNS study in Long-Covid (the study completed 2 years ago but I can't find him publishing on it). He's also running a Sana Pain Reliever study in post treatment Lyme disease. Much to the joy of @Jonathan Edwards he recently completed an exercise study in Osteoarthritis with a high risk of bias.
 
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EndME said:
He was also part of one of the Paxlovid trials with negative results and is running a Rapamycin study in LC and ran a VNS study in Long-Covid. He's also running a Sana Pain Reliever study in post treatment Lyme disease. Much to the joy of @Jonathan Edwards he recently completed an exercise study in Osteoarthritis with a high risk of bias.
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Also note that he published an exercise study in Long-Covid of quality much lower than PACE Autonomic conditioning therapy reduces fatigue and improves global impression of change in individuals with post-acute COVID-19 syndrome @dave30th
 
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N_Dina said:


The study “Audio-visual stimulation therapy for chronic neuropathic pain: a sham-controlled randomized clinical trial”.
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This randomized controlled trial explored the efficacy of a wearable Audio-Visual Stimulation neuromodulation device (Sana) as a novel intervention for chronic NP in 75 participants.
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Results​

For the main outcome (Neuropathic Pain Symptom Inventory total), there were statistically significant improvements in the Active arm that were greater than those in the Sham Arm at Week-14 (Mean Difference = 8.75, p = 0.021). Both groups showed significant improvements at the end of the treatment period (Week-10), and the Active arm maintained this improvement after an additional 4 weeks of non-use, while the Sham arm almost returned to baseline (Active Change = 11.7, p < = 0.001 | Sham Change = 3, p = 0.24). Participants in the Active arm had significant decreases in use of anxiolytic, opiate, antidepressant, and anticonvulsant medications compared to the Sham arm.

Conclusions​

The study provides strong evidence supporting the efficacy of a novel AVS Device in generating durable improvements in NP, with superiority over Sham at 14 weeks. The Sana device may also reduce the reliance on pain medications and is a safe and easy to use treatment option for patients
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It's so obvious once you see it, but outside of biomedical research, medicine has almost completely abandoned even the pretense of plausibility. Any dumb thing for any reason in any combination is worth trying, dozens and dozens of identical times, if it's popular enough. And if it's really popular, then it's worth trying indefinitely. Literally.

I have no doubt that if science and technology stopped progressing, if no more answers came out of basic research and biomedical science, fortunately not a credible scenario, then medicine could genuine, seriously reach its millionth trial of CBT for something or another and never find fault with that. I mean that 100% seriously. They can't stop the gravy trolley, it just rolls on its own inertia now, and the heavier it is the more force it has because it's set up to run downhill.

Almost all of evidence-based medicine, and all of biopsychosocial/psychosomatic ideology, is nothing more than a clickfluencer economy. Whatever gets people to applaud like seals, doesn't matter how ridiculous, is what gets all the attention, which then gets more seal-clapping, and so on. All based on culture. This stuff is simply Traditional Western Medicine.

And yet biomedical research is still producing incredible results, so all of this is a choice between something that works incredibly well, and something that has never once worked, and the choice is almost universal that the implausible garbage feels so much better.
 
rvallee said:
It's so obvious once you see it, but outside of biomedical research, medicine has almost completely abandoned even the pretense of plausibility. Any dumb thing for any reason in any combination is worth trying, dozens and dozens of identical times, if it's popular enough. And if it's really popular, then it's worth trying indefinitely. Literally.

I have no doubt that if science and technology stopped progressing, if no more answers came out of basic research and biomedical science, fortunately not a credible scenario, then medicine could genuine, seriously reach its millionth trial of CBT for something or another and never find fault with that. I mean that 100% seriously. They can't stop the gravy trolley, it just rolls on its own inertia now, and the heavier it is the more force it has because it's set up to run downhill.

Almost all of evidence-based medicine, and all of biopsychosocial/psychosomatic ideology, is nothing more than a clickfluencer economy. Whatever gets people to applaud like seals, doesn't matter how ridiculous, is what gets all the attention, which then gets more seal-clapping, and so on. All based on culture. This stuff is simply Traditional Western Medicine.

And yet biomedical research is still producing incredible results, so all of this is a choice between something that works incredibly well, and something that has never once worked, and the choice is almost universal that the implausible garbage feels so much better.
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It seems like you're overindexing on this.

David Putrino has publicly stated that his strategy is to get manufacturers to fund trials privately. The fact that his trials look like this is unsurprising.

Remember, he's just one researcher of many.
 
Liface said:
It seems like you're overindexing on this.

David Putrino has publicly stated that his strategy is to get manufacturers to fund trials privately. The fact that his trials look like this is unsurprising.

Remember, he's just one researcher of many.
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Any word on that viral persistence test you mentioned you were working towards?
 


“
Great piece from @thesicktimes about our participation in some #LongCOVID and infection-associated chronic condition and illness education in Santa Barbara. Great coverage of some of the challenges of CME-accredited education as well as the need for thesicktimes.org/2026/03/30/cal…
1/“

Haven’t read….

thesicktimes.org

California clinicians gather for Long COVID forum. Recent guides offer direction. - The Sick Times

Clinicians and people with Long COVID gathered in Santa Barbara, California, in late March for a forum on advancing clinical care in infection-associated chronic conditions.
thesicktimes.org thesicktimes.org
 
Great piece from @thesicktimes about our participation in some #LongCOVID and infection-associated chronic condition and illness education in Santa Barbara. Great coverage of some of the challenges of CME-accredited education as well as the need for thesicktimes.org/2026/03/30/cal…
1/“

Haven’t read….

thesicktimes.org

California clinicians gather for Long COVID forum. Recent guides offer direction. - The Sick Times

Clinicians and people with Long COVID gathered in Santa Barbara, California, in late March for a forum on advancing clinical care in infection-associated chronic conditions.
thesicktimes.org thesicktimes.org
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Lots of information in that piece from The Sick Times.

I imagine it is very hard for journalists like those at The Sick Times to be critical of celebrity LC doctors. Keeping them on side helps ensure ongoing access to information, and a lot of potential subscribers will be strong supporters of those doctors. That's a genuine observation, not a criticism. It's very hard to criticise the doctors who are widely regarded as helping (and who genuinely believe that they are). I'm well aware of how it's possible to be isolated from many in the ME/CFS community if you choose to criticise the doctors pushing unevidenced treatments.


Putrino - treat the drivers of infection associated chronic conditions, not the symptoms:
During his talk, Putrino went over ten possible “drivers” of IACCs, including pathogen persistence, pathogen reactivation, mitochondrial dysfunction, vascular dysfunction, dysautonomia, mast cell activation, and more. Rather than treating symptoms of IACCs — which, in the case of Long COVID, include more than 200 — he urged providers to treat “drivers” of symptoms.

Putrino told clinicians to treat each case of Long COVID individually, since the disease is so complex. “When you’ve seen one Long COVID patient, you’ve seen one Long COVID patient,” he said. “We need providers to understand that this is not a silver bullet issue.”
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Apparently 'learning to do no harm includes being on the edge of medicine':
Viswanathan said that in her experience, she has found the heart failure drug ivabradine to be helpful for some people with Long COVID. She has had success with insurance covering it when patients are diagnosed with inappropriate sinus tachycardia (IST), a type of dysautonomia.

While there are no currently FDA-approved treatments for Long COVID, Viswanathan urged providers to consider prescribing medications off-label, as some may help improve quality of life. “Learning to do no harm also needs to include being on the edge of medicine,” she said.
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We have a proliferation of treatment guides right now.
On top of the CoRE and Bateman Horne Center guides, the Patient-Led Research Collaborative and the telehealth clinic RTHM recently published a Long COVID Treatment Guide with potential off-label drugs, supplements, and lifestyle interventions for people with the disease to discuss with providers who may not be informed on Long COVID.
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A Google executive has a son with LC and 'ME':
Three patients and one caregiver, Royal Hansen, the vice president of privacy, safety, and security engineering at Google, joined the panel. He spoke about his 10-year-old son’s experience with severe Long COVID and myalgic encephalomyelitis (ME). The illnesses have left Hansen’s son bed- and homebound, and unable to attend school. Before, he was active and enjoyed playing many sports.

“Little by little, everyone forgot about him,” Hansen said, joining virtually from Utah. “It’s a little bit surreal,” he said about the isolation his family experiences because of his son’s illness. Hansen described significant trouble for his family in finding care for their son. While they moved from California to Utah to access better care, he said his son is “basically in the same place” and that some treatments they have tried have made him worse.
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A forthcoming pediatric LDN trial:
Guidance for Long COVID in children has moved at a glacial pace, and there have been only a handful of pediatric clinical trials. RECOVER has plans for a trial on low-dose naltrexone (LDN) in children that will begin recruiting later this year, and only a few other trials are scattered around North America.
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Is it RECOVER that has been running an adult LDN trial? Would they have any results at this point?
 
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