The effect of exertion is unpleasant. It's not immediate. Here it starts next day but 48hours sees it peaking - the descent time varies.
Energy impact is complex as it is not a constant, even for routine things :
I think at certain life stages ( puberty / menopause / if a child simply growing) the body's preprogrammed processes precedence can knock things out significantly as they consume a lot of energy and you can't avoid them.
Emotional impact is the hardest to predict/ manage/ gauge.
I thought the Myhill hypothesis on PEM made sense. Having depleted ATP/ ADP and limited recycling of AMP via whatever mechanism ( more energy intensive) to manufacture ATP from scratch takes time.
Having limited availability of cofactors doesn't help. Being at wrong core body temperature doesn't help.
I would agree re signalling probably being the issue, but does signalling alone account for the heterogeneity?
Energy impact is complex as it is not a constant, even for routine things :
I think at certain life stages ( puberty / menopause / if a child simply growing) the body's preprogrammed processes precedence can knock things out significantly as they consume a lot of energy and you can't avoid them.
Emotional impact is the hardest to predict/ manage/ gauge.
I thought the Myhill hypothesis on PEM made sense. Having depleted ATP/ ADP and limited recycling of AMP via whatever mechanism ( more energy intensive) to manufacture ATP from scratch takes time.
Having limited availability of cofactors doesn't help. Being at wrong core body temperature doesn't help.
I would agree re signalling probably being the issue, but does signalling alone account for the heterogeneity?