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Unraveling the Molecular Determinants of Manual Therapy: An Approach to Integrative Therapeutics for the Treatment of Fibromyalgia and CFS/ME

Discussion in 'BioMedical ME/CFS Research' started by Sly Saint, Sep 9, 2018.

  1. Sly Saint

    Sly Saint Senior Member (Voting Rights)

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    Unraveling the Molecular Determinants of Manual Therapy: An Approach to Integrative Therapeutics for the Treatment of Fibromyalgia and Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

    Received: 2 July 2018 / Revised: 4 September 2018 / Accepted: 7 September 2018 / Published: 9 September 2018


    José Andrés Espejo 1,†, María García-Escudero 2,† and Elisa Oltra 3,4,*
    1
    School of Experimental Sciences, Universidad Católica de Valencia San Vicente Mártir, 46001 Valencia, Spain
    2
    School of Physiotherapy, Universidad Católica de Valencia San Vicente Mártir, 46900 Valencia, Spain
    3
    School of Medicine, Universidad Católica de Valencia San Vicente Mártir, 46001 Valencia, Spain
    4
    Unidad Mixta CIPF-UCV, Centro de Investigación Príncipe Felipe, 46012 Valencia, Spain

    These authors contributed equally to this work.

    http://www.mdpi.com/1422-0067/19/9/2673
     
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  2. Denise

    Denise Senior Member (Voting Rights)

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    Thanks for posting this @Sly Saint .
    I haven't had a chance to read it yet but I notice Elisa Oltra is one of the authors. She was on the NIH CDE project. I also see that Rowe's work on manual therapy is referenced.
     
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  3. Diwi9

    Diwi9 Senior Member (Voting Rights)

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    I appreciate the explanation provided by the authors here: "Benefits from CBT/GET therapy have also been reported for CFS/ME patients by other CTs (the PACE trials) including 160 participants per group, when compared to specialist medical care (SMC) alone or adaptive pacing therapy (APT) [30]. The authors of the PACE trials claim that the beneficial effects were maintained for one year at long-term follow-up, with a median of 2.5 years after randomization [31]. However, serious study design concerns have been raised by the scientific community regarding the inappropriate case definition of enrolled participants, scores that do not support significant improvement of fatigue and physical functioning at long-term, plus data indicative of subjective improvement by specialist medical care and APT to the same level as by CBT and GET, or without any additional therapies [32,33]."
     
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  4. Jonathan Edwards

    Jonathan Edwards Senior Member (Voting Rights)

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    I am not sure what animal models would be relevant. This looks a bit airy fairy to me.
     
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  5. NelliePledge

    NelliePledge Moderator Staff Member

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    I just had a weird image of someone doing physio on a mouse
     
  6. MeSci

    MeSci Senior Member (Voting Rights)

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    If only animal experiments were so gentle and harmless...
     
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  7. MEMarge

    MEMarge Senior Member (Voting Rights)

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    I ended up reading some research on tilt-table testing in mice! Can't remember where now, probably a few clicks on from a POTS or Dysautonomia website.
     
  8. rvallee

    rvallee Senior Member (Voting Rights)

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    I don't remember the source, but a POTS study did tilt table tests on mice.

    So someone built a tiny weeny little mouse-sized tilt table and I just can't get out of my head how adorable that is.

    LOL @MEMarge thinking the same :)
     
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  9. MeSci

    MeSci Senior Member (Voting Rights)

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    You do know that experimental animals are almost always killed afterwards, don't you?
     
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