Unraveling the Molecular Determinants of Manual Therapy: An Approach to Integrative Therapeutics for the Treatment of Fibromyalgia and CFS/ME

Unraveling the Molecular Determinants of Manual Therapy: An Approach to Integrative Therapeutics for the Treatment of Fibromyalgia and Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

Received: 2 July 2018 / Revised: 4 September 2018 / Accepted: 7 September 2018 / Published: 9 September 2018


José Andrés Espejo 1,†, María García-Escudero 2,† and Elisa Oltra 3,4,*
1
School of Experimental Sciences, Universidad Católica de Valencia San Vicente Mártir, 46001 Valencia, Spain
2
School of Physiotherapy, Universidad Católica de Valencia San Vicente Mártir, 46900 Valencia, Spain
3
School of Medicine, Universidad Católica de Valencia San Vicente Mártir, 46001 Valencia, Spain
4
Unidad Mixta CIPF-UCV, Centro de Investigación Príncipe Felipe, 46012 Valencia, Spain
†
These authors contributed equally to this work.

http://www.mdpi.com/1422-0067/19/9/2673

 

Thanks for posting this @Sly Saint .
I haven't had a chance to read it yet but I notice Elisa Oltra is one of the authors. She was on the NIH CDE project. I also see that Rowe's work on manual therapy is referenced.

 

I appreciate the explanation provided by the authors here: "Benefits from CBT/GET therapy have also been reported for CFS/ME patients by other CTs (the PACE trials) including 160 participants per group, when compared to specialist medical care (SMC) alone or adaptive pacing therapy (APT) [30]. The authors of the PACE trials claim that the beneficial effects were maintained for one year at long-term follow-up, with a median of 2.5 years after randomization [31]. However, serious study design concerns have been raised by the scientific community regarding the inappropriate case definition of enrolled participants, scores that do not support significant improvement of fatigue and physical functioning at long-term, plus data indicative of subjective improvement by specialist medical care and APT to the same level as by CBT and GET, or without any additional therapies [32,33]."

 

I am not sure what animal models would be relevant. This looks a bit airy fairy to me.

 

If only animal experiments were so gentle and harmless...

 

I ended up reading some research on tilt-table testing in mice! Can't remember where now, probably a few clicks on from a POTS or Dysautonomia website.

 

I don't remember the source, but a POTS study did tilt table tests on mice.

So someone built a tiny weeny little mouse-sized tilt table and I just can't get out of my head how adorable that is.

LOL @MEMarge thinking the same

 

You do know that experimental animals are almost always killed afterwards, don't you?