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UK CMRC Conference 2018 - Prof Carmine Pariante

Discussion in 'ME/CFS research news' started by Trish, Oct 9, 2018.

  1. Trish

    Trish Moderator Staff Member

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    Last edited: Oct 9, 2018
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  2. NelliePledge

    NelliePledge Moderator Staff Member

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    well at least nobody can waste money trying to replicate this.
     
  3. Sid

    Sid Senior Member (Voting Rights)

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    So, this talk was more interesting than I anticipated given Pariante's egregious past statement that ME/CFS is caused by 'excessive rest'.

    It appears that the subset of people who develop persistent fatigue following IFN alpha have a significantly higher IL-6 and IL-10 response to treatment than those who do not report persistent fatigue. However, at follow-up assessment (that is to say after completion of therapy) these cytokines have returned to normal levels yet the patients still have higher fatigue levels than at pre-treatment baseline. Therefore, the cytokines are not what's causing the patients to feel rubbish which is just reinventing the wheel really as we've known this for years.

    Pariante points out that in cross-sectional studies of ME/CFS these normal cytokine levels would be seen as evidence of immune system not being imprortant in the illness because the patients who are studied in cross-sectional studies already have an entrenched illness state. This highlights the need for longitudinal study designs since the cytokine elevations occur early on, presumably before the patient has had contact with medics and researchers, so unless you are following people up prospectively you are not going to capture these early immune alterations.

    More importantly, this study showed a clear separation between depression and persistent fatigue. Cytokine levels differed and the usual psychosocial risk factors for depression such as age, gender, ethnicity, education etc. were not predictive of developing chronic fatigue. This part of the talk seemed understated and rushed somewhat. I wonder if these results surprised him given his preexisting BPS bias and he is still trying to process this. He did try to forcefully insert psychosocial risk factors right at the end when he began to speculate on what future studies might show in terms of bodies or immune systems of chronic fatigue patients being 'sensitised' to overreact to future insults.
     
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  4. adambeyoncelowe

    adambeyoncelowe Senior Member (Voting Rights)

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    My guess is that BPSers will claim the two-year window period in which we can detect cytokines is due to illness, but that the post-two-year period is where the illness is perpetuated by deconditioning. You've rested too much while really ill, so now you're just out of shape and phobic!

    In fact, the evidence here does seem, on the surface, to support their hypothesis. It could just be that the inflammation isn't a continuing driver, because the damage has been done (whether that's a metabolic trap, busted signalling, or a combination of things).

    ETA: The press coverage hasn't actually gone this way, so I'm pleased to be wrong. The final study does seem to show that perpetual fatigue is biologically distinct from somatisation and depression.
     
    Last edited: Dec 17, 2018
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  5. NelliePledge

    NelliePledge Moderator Staff Member

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    And it’s not ME patients anyway so how can he even say it is relevant to us
     
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  6. adambeyoncelowe

    adambeyoncelowe Senior Member (Voting Rights)

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    No, but similar responses were noted in ME (raised markers in the first two years that tail off after that). Of course, the third option is that post-two-year patients have immune 'exhaustion' instead, which is why the markers drop.
     
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  7. rvallee

    rvallee Senior Member (Voting Rights)

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    Which is why they never address the common relapsing-remitting course. What, then, causes the relapse for some patients? They just got bamboozled by their own confused senses again? Did they forget they were not deconditioned anymore? Got a sudden "welp, guess I'm sick again" belief?

    During my 3rd remission I was actually capable of doing martial arts. I wasn't at full capacity but I was functional. I relapsed again, twice, into a now permanent state of disability.

    They never bother to address any of this, in large part because it hasn't been studied enough and they just pretend it doesn't exist. I'm pretty sure that average length of illness is skewed by this as well, where I would have been counted 5 times over as having a 1-2 year illness rather than a decade of relapsing-remitting illness.
     
  8. Snowdrop

    Snowdrop Senior Member (Voting Rights)

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    [​IMG]

    Poor dear. He just can't let it (psychosocial) go. Must be a core belief of his world view.
     
  9. Mithriel

    Mithriel Senior Member (Voting Rights)

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    In all the time the BPSers have spouted their theories, they have never once actually looked at patient experience, probably because they knew already that it would show they were talking rubbish.

    They have a beautiful narrative which is easy to understand for politicians and so on, but it could only ever describe chronic fatigue, not the CFS and never ME which had variability of symptoms by the hour, day, month, year as a hallmark. Like the hallmark of getting worse with exertion this had to be ignored.

    It is one of the things I hold against the charities. The usual course of the disease could never be explained by the deconditioning, exercise phobia model and they knew that in 1985 but they did not shout it with a single voice over and over. I have never understood that betrayal.
     
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  10. Trish

    Trish Moderator Staff Member

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    I've just watched this.

    How can he with a straight face describe 'persistent fatigue' as measured with the Chalder Fatigue questionnaire (CFQ) as a proxy for CFS/ME? It may be a 'biomedical' study, but that doesn't mean it has any relevance to ME/CFS. And we all know the problems with CFQ.

    Did any of the interferon treated patients have PEM? I don't suppose it even occurred to him to ask. And if they didn't how can it possibly be a proxy for ME/CFS. He might as well have called it a proxy for MS, since fatigue is one of the symptoms of that too.

    :(
     
    Last edited: Dec 17, 2018
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  11. Snowdrop

    Snowdrop Senior Member (Voting Rights)

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    CP's presentation highlights an important issue. It's not really about psychosocial or even BPS vs biomedical (although the PS/BPS view used as a political tool can go to hell). It's about sound scientific methods and having some intelligence about what that tells us.
     
  12. Andy

    Andy Committee Member

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    The man is obviously a medical genius! According to the Mayo Clinic website, he has discovered a proxy for all of these...
    Surely in order to validate his model he would need to compare and contrast patients suffering from all of these?
     
  13. Andy

    Andy Committee Member

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    The project details can be found here, https://gtr.ukri.org/projects?ref=MR/J002739/1

    I especially liked this bit
    How does an existing study, and established collaboration and existing clinical services affect the chances of success? The man's logic is beyond me.
     
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  14. Simon M

    Simon M Senior Member (Voting Rights)

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    Persistent fatigue as a model for CFS

    Sorry about the length of this: would have been shorter if I'd had more energy

    Concerns about this research have already been covered well: Pariente's strong belief that ME/CFS is a psychosocial illness; that this isn't a study of ME/CFS itself, but a proposed model; that it only considers fatigue and not PEM, yet doesn't consider this to be a model of other fatiguing illnesses. Not to mention that the model is is a dead duck because new treatments for hepatitis C means that interferon alpha therapy is now obsolete.

    Even so, as @Sid has already said, there are reasons to give the study serious consideration.

    One is that the model might just reveal something useful about a hit-and-run scenario where ME/CFS starts as a result of a one off infection or other immune insult. Many researchers consider this scenario quite possible and the results of the new study tally with those of the original Dubbo study. The other reason is that if this is a decent model for CFS, it provides both evidence for a biomedical explanation and evidence against a psychosocial one. This was a Bake off between psychosocial and biomedical explanations of persistent fatigue, and it wasn't even close.
    ___​

    The possible relevance of the model

    The problem with ME/CFS is that cases aren't diagnosed until long after the initial infection has resolved and very often there are few biological abnormalities to be seen. And while there is a reasonable understanding of the biology behind other illnesses with substantial levels of fatigue, including cancer, MS and rheumatoid arthritis, we are still largely in the dark about ME/CFS. This model has (or had) the potential shed some light on things.

    For instance, although researchers often report cytokine differences between ME/CFS patients and healthy controls, these are quite small and are not really sufficient to explain an illness of this severity. Is the finding just a secondary association? What would really help is a prospective approach, studying the illness as it develops because changes that happened as the illness sets in are much more likely to be causal than ones that are simply associated with a long-standing disease.

    The best example of this prospective approach is the Dubbo study of post-infectious CFS set in the Australian outback. This study found that what predicted CFS at six months following three different acute infections (glandular fever/EBV, Ross River virus and Q fever) was the severity of the initial illness, and not by demographic or psychosocial factors. However, six months after the initial infection, cytokine levels were back to normal in both the ME/CFS and recovered groups. The study authors suggested there could be a hit-and-run mechanism to CFS where an initial severe illness led to long-term changes in biology (I think they were the first to suggest the brain's microglia were playing a role) that sustained ME/CFS.

    The key thing about Dubbo is that it followed new cases from the initial infection through to developing of CFS. Pariente's work had aimed to create a more convenient model for studying the onset of fatigue following an immune insult. It was based on the treatment of hepatitis C patients with interferon alpha which was known to cause persistent fatigue in some after the interferon therapy had stopped. Sure, this only looked at fatigue, and fatigue levels were substantially less than those seen in ME/CFS but it could be reveal something useful.

    Jarred Younger is key proponent of the view that an initial immune insults leads to primed microglia in the brain and that is responsible for ME/CFS, so this is relevant to an important mainstream theory. (Normally, an infection leads to an increase in cytokines e.g interferon-alpha, which in turn activate microglia, leading to the sickness response inc fatigue, malaise and problems concentrating. This should unwind when the infection ends but might not in mecfs.) In 2014, a Japanese study found neuroinflammation - microglial activation) in ME/CFS patients — work that is now been followed up by Maureen Henson, Michael VanElzakker and Ron Davies — as well as Younger himself.


    The study, its results and how they fit with Dubbo
    The study uses interferon alpha treatment of hepatitis C patients, which dramatically reduces the level of virus, but also causes substantial fatigue during therapy. For most patients, at the end of the study fatigue levels fall back to normal, healthy levels "resolved fatigue, RF" (unsurprising, since the level of hepatitis C has been brought under control). But around one third of those who have treatment experience persistent fatigue, PF, after the treatment has ended, and they are the focus of this study. Its strength is that researchers can measure features of patients both before and during treatment to see if they predict or explain which patients go on to develop persistent fatigue.

    Results
    What they found was that those who developed persistent fatigue had higher fatigue levels during treatment, higher levels of pro-inflammatory cytokine IL-6 and the anti-inflammatory cytokine IL-10, and had more treatment sessions or sessions over a longer period than patients who did not develop persistent fatigue. In contrast, there were no differences between the groups in demographics or what Pariente described as "classical psychosocial" factors. In other words, the research looked at both biological and psychosocial factors and discovered it was biological factors that predicted persistent fatigue.

    Pariente said that having treatment spread over a longer period, and also having more sessions in total was associated with persistent fatigue.

    Fatigue results (note that fatigue levels are much lower than activity seen in ME/CFS):

    88735296-E6D8-499D-AECE-64D5E54FDC52.jpeg

    Cytokine results:

    86EDBB81-161E-4D08-8E1C-D709ABBF3BD0.jpeg
    It is a little strange that both pro-inflammatory and anti-inflammatory cytokines where elevated; Pariente suggested that the increase in the anti-inflammatory IL -10 might be the body trying to dampen down inflammation. Interferon alpha itself is strongly pro-inflammatory and is other work on this treatment shows that interferon alpha does ramp up inflammation in the body.

    However, there was no difference between the persistent fatigue group and the result fatigue group at six months.

    Vs Dubbo
    The Dubbo results were not so different. Baseline psychosocial factors did not significantly predict developing CFS, but the severity of the initial illness did, and there was some evidence of a stronger proinflammatory cytokine response during the infection in those that went on to develop CFS.

    For any given infectious agent, much of the difference in illness severity betweeen patients is down to their immune response: a stronger immune response makes you feel sicker. So both Dubbo (severe illness) and the interferon alpha treatment (the length of inteferon treatment and number of sessions, level of other cytokines, and fatigue) indicate the strength of immune response is key. Pariente suggested that it might be that having longer or more severe immune activation during the initial illness could be in an important factor risk factor for ME/CFS.



    Pariente's view of the future

    At the end of the presentation he made the assumption that the model was married to ME/CFS and appeared to be pursuing a largely biological line of enquiry:

    What is abnormal about those who develop chronic fatigue syndrome, why did they have the stronger immune response?

    He speculated that this could be down to priorinfection, within the womb or during early childhood. He felt that might sensitise the immune system and subsequently, when someone has an infection (or psychosocial issues!) That might trigger an abnormally large immune response and lead to ME/CFS. Pariente was still very interested in the role of psychosocial factors, but that was speculation — the evidence was own study was about the importance of biomedical factors rather than psychosocial ones.

    Given that is hepatitis C model is now redundant, Pariente suggested that what was needed was defined other groups persistent fatigue were similar prospective approach could be used.

    Dubbo Mark 2?
    I would suggest that better still would be a Dubbo 2.0 study, prospectively following new cases of glandular fever. There are no shortage of glandular fever cases in the UK and this approach has a huge advantage of allowing the study of ME/CFS as it develops. The drawback is that you don't have data at baseline, before the infection strikes, and you don't have the convenience of patients regularly attending hospital treatment, when blood samples et cetera can be taken.
     
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  15. obeat

    obeat Senior Member (Voting Rights)

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    Some PWME say they never get viral infections, whilst others ( myself included) seem to richochet from one to the next. Do you think this implies differences in the immune system, so researchers need to look for subgroups?
     
  16. Sid

    Sid Senior Member (Voting Rights)

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    I don't think this study should be dismissed out of hand just because of the author's BPS allegiances. Although this is not an ME/CFS study per se (since he did not measure PEM), it still tells us something interesting about the relationship between early immune activation and persistent fatigue and lack of relationship between psychosocial factors and persistent fatigue. It's always nice to see a psychiatrist present his own data that do not support his psychosocial theory of causation. :whistle:
     
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  17. Cheshire

    Cheshire Moderator Staff Member

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    The paper is out: see this thread.
     
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  18. Dolphin

    Dolphin Senior Member (Voting Rights)

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  19. Andy

    Andy Committee Member

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