Two-stage metabolic remodelling in macrophages in response to lipopolysaccharide and interferon-γ stimulation, 2020, Seim et al.

I'm always interested to see theories where LPS can trigger PEM-like symptoms. I have poor digestion and often digestive disturbances can leave me exhausted and very brainfogged.

I've come to think of that as leaky gut pushing LPS into the blood.

Duration is usually not as bad as PEM from exericse. The two can stack though.

 

It might not identify the mechanism, but a reliable response from the majority of PWME would be valuable, if for nothing more than verifying that ME is biological rather than psychological. It needn't be a cytokine; I just think it's likely that a cytokine would affect ME symptoms. That's just my experience with immune activation of various types worsening my ME symptoms.

 

A close relative was having interferon treatment for Hep. C the same year of my very severe ME onset. His symptoms sounded like mine. I remember thinking that his symptoms would be turned off eventually, but mine were uncontrolled and no help in sight. I did post about this year's ago on PR.