Two interesting new studies on how inactivity can have drastic metabolic consequences. Take a Vacation From Exercise? Your Body May Not Thank You This is by no means a suggestion that PWME should be more active, of course adaptive pacing is the best way to go! It just highlights one of the possible downstream effects of having ME. It is very interesting that physical inactivity can quickly cause metabolic dysfunction, higher blood glucose, and impaired insulin sensitivity in otherwise healthy people. I wonder if it might even be worse in PWME since activity levels are likely much lower. ++ @Silencio on PR for mentioning this article.