1. Guest, the 'News in Brief' for the week beginning 10th January 2022 is here.
    Dismiss Notice
  2. Welcome! To read the Core Purpose and Values of our forum, click here.
    Dismiss Notice

Trial of Long Covid treatment - AXA1125 from Axcella Therapeutics, 2021

Discussion in 'Epidemics (including Covid-19)' started by rvallee, Oct 30, 2021.

  1. rvallee

    rvallee Senior Member (Voting Rights)

    Messages:
    7,973
    Location:
    Canada
    Oxford to test potential treatment for fatigue in long COVID patients
    https://www.ox.ac.uk/news/2021-10-29-oxford-test-potential-treatment-fatigue-long-covid-patients

    Dr Alison Schecter, President of R&D at Axcella, said: 'While Long COVID’s enormous patient and socioeconomic burden has become apparent, its underlying pathophysiology is now emerging,” said . “In two prior successful clinical studies and in preclinical models, AXA1125 has demonstrated an ability to reverse mitochondrial dysfunction and improve energetic efficiency via increased fatty acid oxidation, restored cellular homeostasis, and reduced inflammation. This provides us with confidence about its potential to help the growing number of patients who are suffering from COVID’s debilitating effects long after contracting the virus.”

    The Phase 2a trial will be a randomized, double-blind, placebo-controlled investigation to evaluate the efficacy and safety of AXA1125 in patients with exertional fatigue related to Long COVID. Approximately 40 patients will be enrolled and randomized evenly to receive either AXA1125 or a matched placebo.

    Unimpressed by the insistence to reduce everything to fatigue but whatever...
     
    Milo, EzzieD, sebaaa and 18 others like this.
  2. Wonko

    Wonko Senior Member (Voting Rights)

    Messages:
    5,570
    Location:
    UK
    It does seem that fatigue is the medical equivalent of chicken.
     
    FMMM1, EzzieD, sebaaa and 17 others like this.
  3. ArtStu

    ArtStu Established Member (Voting Rights)

    Messages:
    49
    Location:
    UK
    I'm quietly hopeful of this working, it seems to fit with my feelings about what is wrong with me.
     
    janice, Kitty, Daisymay and 2 others like this.
  4. Hutan

    Hutan Moderator Staff Member

    Messages:
    17,614
    Location:
    Australia
    https://www.clinicaltrialsarena.com/news/axcella-trial-long-covid-treatment/

     
    sebaaa, Kitty, Daisymay and 2 others like this.
  5. chillier

    chillier Established Member (Voting Rights)

    Messages:
    25
    Is anything known about its mechanism of action? Is this a small molecule with a known target?
     
    janice, Kitty, Daisymay and 1 other person like this.
  6. chillier

    chillier Established Member (Voting Rights)

    Messages:
    25
    From the Axcella website: "AXA1125 is an EMM composition of six amino acids and derivatives."

    If it is simply amino acids then is this essentially a nutritional supplement?

    67.8 grams sounds like a lot!
     
    FMMM1, sebaaa, Anna H and 7 others like this.
  7. Kitty

    Kitty Senior Member (Voting Rights)

    Messages:
    2,595
    Location:
    UK
    :eek: Certainly if it's in solid form...

    Even one gram (equal to a normal adult dose of 2 x paracetamol/acetaminophen tablets) is a lot to swallow!!
     
    NelliePledge, Ash and ArtStu like this.
  8. Wonko

    Wonko Senior Member (Voting Rights)

    Messages:
    5,570
    Location:
    UK
    When I've taken amino acids such as BCAA it's in powder form mixed into a shake, drink, as with capsules I'd be taking than all day.

    10 to 15g of powder in 200ml of liquid is not unusual, more if it's a whey based shake mix with something else added, where the whey component is 30g per 200ml of liquid, and then another 15g on top in the same 200ml of liquid.

    One drink, 45g of powder, vs 45 capsules, for the same dose amount.
     
    EzzieD, Mij, Kitty and 4 others like this.
  9. chrisb

    chrisb Senior Member (Voting Rights)

    Messages:
    4,368
    They probably think we should have no difficulty. After all, we've had to swallow an awful lot over the years.
     
    EzzieD, sebaaa, Wits_End and 12 others like this.
  10. Trish

    Trish Moderator Staff Member

    Messages:
    38,142
    Location:
    UK
    Amino acids are the constituents of protein.

    Edit: It appears from a later post on this thread that there's a misplaced decimal point. The dose is more like 6g, not 60g.

    So if people are being dosed with 67.8g amino acids daily, that's more than doubling their protein intake. I assume it's a particular secret mix of aa's, possibly as others are suggesting bcaa's which I am aware some people with ME take on the basis that they are supposed to help energy production, if I remember correctly as an alternative energy source to glucose (carbs) to feed into the citric acid cycle in the mitochondria.

    Do correct me if this does't make sense.

    ___________________

    There seems to be some doubt about this as a measure.

    1999
    Skeletal muscle phosphocreatine recovery in exercise-trained humans is dependent on O2 availability
    L J Haseler 1, M C Hogan, R S Richardson
    Affiliations
    ____________________

    Letters to the Editor (Nature, 2012)

    Can we simply infer mitochondrial function from PCr resynthesis after exercise in skeletal muscle?
    says this:
     
    Last edited: Nov 4, 2021
    EzzieD, sebaaa, Kitty and 4 others like this.
  11. Hutan

    Hutan Moderator Staff Member

    Messages:
    17,614
    Location:
    Australia
    Sounds like the treatment is the equivalent of chicken.
     
    ladycatlover, FMMM1, EzzieD and 11 others like this.
  12. Fizzlou

    Fizzlou Established Member (Voting Rights)

    Messages:
    60
    Location:
    Cheshire
    janice, sebaaa, Anna H and 8 others like this.
  13. Wyva

    Wyva Senior Member (Voting Rights)

    Messages:
    566
    Location:
    Hungary
  14. Kitty

    Kitty Senior Member (Voting Rights)

    Messages:
    2,595
    Location:
    UK
    I take them because they reduce PEM and help me digest carbs, but I've no idea why.

    I once spent six or seven weeks getting though a tub of identical-looking but different supplements, which I'd picked up thinking they were BCAAs. I cursed the brand for selling fakes because they didn't work at all, but I couldn't afford a replacement tub. I only actually noticed when I washed out the jar for recycling that they were creatine or something.

    :rolleyes:
     
    FMMM1, janice, Hutan and 2 others like this.
  15. wastwater

    wastwater Senior Member (Voting Rights)

    Messages:
    282
    Could it work like copaxone by offering up a decoy to antibodies
     
  16. Mij

    Mij Senior Member (Voting Rights)

    Messages:
    5,420
    I had custom formulas made up based on my amino acid profile panels etc and they made no difference.
     
    cfsandmore, janice, ukxmrv and 4 others like this.
  17. Michiel Tack

    Michiel Tack Senior Member (Voting Rights)

    Messages:
    2,799
    Location:
    Belgium
    The Guardian article states:

    "Further investigation revealed that they were accumulating lactic acid in their muscles at a faster rate than healthy individuals – a possible sign of mitochondrial dysfunction."​

    Does anyone know which long covid study they might be referring to?
     
    FMMM1, janice, Dolphin and 4 others like this.
  18. Dolphin

    Dolphin Senior Member (Voting Rights)

    Messages:
    3,195
    From:
    Safety, Tolerability, and Biologic Activity of AXA1125 and AXA1957 in Subjects With Nonalcoholic Fatty Liver Disease
    https://journals.lww.com/ajg/Fulltext/9900/Safety,_Tolerability,_and_Biologic_Activity_of.62.aspx
     
    Last edited: Nov 5, 2021
    Hutan, Trish, ArtStu and 1 other person like this.
  19. Trish

    Trish Moderator Staff Member

    Messages:
    38,142
    Location:
    UK
    So the doses are more like 6 g, not 60g as someone said earlier on the thread. That makes more sense.
     
    janice and Hutan like this.
  20. Wonko

    Wonko Senior Member (Voting Rights)

    Messages:
    5,570
    Location:
    UK
    Those are also seemingly fairly standard components at pretty low dosages.

    I can't believe that none of us have used them.

    I probably have, with the exception of glutamine, as far as I remember.

    Not a wonder drug.
     
    Hutan, 5vforest, ArtStu and 1 other person like this.

Share This Page