The increased cellular permeability syndrome manifesting as severe idiopathic type urinary incontinence, 2019, Check & Check

[Dolphin]

Free full text:
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CEOG Clinical and Experimental
Obstetrics & Gynecology
7847050 Canada Inc.
www.irog.net

Clin. Exp. Obstet. Gynecol. - ISSN: 0390-6663
XLVI, n. 5, 2019
doi: 10.12891/ceog5179.2019

The increased cellular permeability syndrome manifesting as severe idiopathic type urinary incontinence
J.H. Check1,2, D. Check2
1Cooper Medical School of Rowan University, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ
2Cooper Institute for Reproductive Hormonal Disorders, P.C. Mt. Laurel, NJ (USA)

Summary
Purpose: To evaluate the efficacy of treatment with dextroamphetamine sulfate for severe idiopathic urgency urinary incontinence refractory to treatment with the selective beta 3 adrenergic agonist, mirabegron.

Materials and Methods: Dextroamphetamine sulfate extended release capsule was started at 9.4 mg and increased to 15.7 mg in a woman with two years of severe urgency urinary incontinence.

Results: The urgency urinary incontinence completely resolved, as did the fibromyalgia, headaches, and chronic fatigue syndrome. The symptoms have remained eradicated for over one year while treatment continues.

Conclusions: Idiopathic urgency urinary incontinence (neurogenic bladder) has been found to be another manifestation of the increased cellular permeability syndrome. Similar to the other chronic disorder associated with the increased cellular permeability syndrome, idiopathic urgency urinary incontinence responds well to dextroamphetamine sulfate treatment despite failure to respond to standard therapy.

Key words: Idiopathic urgency urinary incontinence; Neurogenic bladder; Dextroamphetamine sulfate; Increased cellular permeability
syndrome; Dopamine.

 

[Jonathan Edwards]

This syndrome seems to have been invented by the authors and there seem to be no papers about it by anyone else.

I am not sure what the abstract is supposed to mean.

 

[rvallee]

There's a whole lot to unpack here and I'm not sure how we get from cellular permeability to urinary incontinence and sprinkle in some fibromyalgia and CFS in the process.

https://www.researchgate.net/public..._The_increased_cellular_permeability_syndrome

Purpose: To provide examples of other conditions that are improved following treatment with dextroamphetamine sulfate that would not involve hyperalgesia and/or edema. Thus elucidation of such conditions would demonstrate the need to change the name from the sympathetic neural hyperalgesia syndrome to a name that would cover all conditions responding to sympathomimetic amine therapy. Materials and Methods: Cases of chronic fatigue syndrome and various skin and neurologic disorders and temperature regulation conditions are provided as examples of conditions responding well to dextroamphetamine sulfate that do not involve either pain or edema. Results: Examples are provided that show that inherited permeability defects in certain tissues or inherited sympathetic nervous system hypofunction produce symptoms other than pain or swelling yet respond to dextroamphetamine sulfate. Conclusions: Though lacking "pizzazz", the new name given to this condition refers to the main hypothesized defect whether inherited or acquired, and that is increased cellular permeability. Thus, the new name is the increased cellular permeability syndrome in lieu of the sympathetic neural hyperalgesia - edema syndrome which had replaced the name idiopathic edema.

Uhhhh. Yeah I'll just pretend the last 5 minutes of my life were actually a vivid sensory hallucination and move on.

 

[alktipping]

is there anything that is considered as unpublishable by these editors or has publishing turned into a free for all .

 

[Jonathan Edwards]

is there anything that is considered as unpublishable by these editors or has publishing turned into a free for all .

Actually it has turned into a quite expensive for all. Generally speaking people have to pay to get their rubbish published. But in the metaphorical sense yes, journals will publish anything. They email me every day to ask if I have something I want them to publish, despite not knowing who I am. They also email me to ask if I would like to sit on their editorial board, despite not knowing who I am.