The deubiquitinase MYSM1 dampens NOD2-mediated inflammation and tissue damage by inactivating the RIP2 complex

[leokitten]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220254/

Very interesting paper which has identified MYSM1, a part of the ubiquitin system that acts as a molecular switch to deactivate the innate immune system and has the ability to prevent certain diseases caused by an excessive activation of the immune system.

See also news article: https://apple.news/Aa3xJm8mHQNafvg9Lya38zg

 

[obeat]

https://www.ncbi.nlm.nih.gov/pubmed/30076785
Another paper on ubiquitin and antigenic mimicry