innate immune system

  1. SNT Gatchaman

    Butyrate Selectively Targets Super-Enhancers and Transcriptional Networks Associated with Human Mast Cell Function, 2025, Folkerts et al.

    Butyrate Selectively Targets Super-Enhancers and Transcriptional Networks Associated with Human Mast Cell Function Jelle Folkerts; Marjolein J. W. de Bruijn; Wilfred F. J. van IJcken; Rudi W. Hendriks; Ralph Stadhouders Mast cells are key drivers of allergic inflammation. We have previously...
  2. SNT Gatchaman

    Review Mitochondrial innate immune signaling in skeletal muscle adaptation to exercise, 2025, Ma, Hwang et al.

    Mitochondrial innate immune signaling in skeletal muscle adaptation to exercise Jin Ma; Annie Yujin Son; Youlim Son; Ping-yuan Wang; Paul M. Hwang Exercise-induced inflammation is regarded as a response to muscle damage from mechanical stress, but controlled immune signaling can be beneficial...
  3. SNT Gatchaman

    Gastrointestinal Barrier Disruption in Post-COVID Syndrome Fatigue Patients, 2025, Rohrhofer et al.

    Gastrointestinal Barrier Disruption in Post-COVID Syndrome Fatigue Patients Johanna Rohrhofer; Viktoria Wolflehner; Johannes Schweighardt; Larissa Koidl; Michael Stingl; Sonja Zehetmayer; Joana Séneca; Petra Pjevac; Eva Untersmayr BACKGROUND Post-COVID Syndrome (PCS) is the term for a condition...
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    • gastrointestinal gastrointestinal symptoms gut barrier gut microbiome il-33 innate immune system zonulin
    • Replies: 3
    • Forum: Long Covid research
  4. jnmaciuch

    Interferon Gamma Induces Reversible Metabolic Reprogramming of M1 Macrophages, 2018, Wang et al.

    Interferon Gamma Induces Reversible Metabolic Reprogramming of M1 Macrophages to Sustain Cell Viability and Pro-Inflammatory Activity Feilong Wang ∙ Song Zhang ∙ Ryounghoon Jeon ∙ Ivan Vuckovic ∙ Xintong Jiang∙ Amir Lerman∙ Clifford D. Folmes ∙ Petras D. Dzeja ∙ Joerg Herrmann Highlights...
  5. SNT Gatchaman

    Preprint Unveiling the Immune Landscape of COVID-19 and prolonged Long-COVID through Single-Cell RNA Sequencing, 2025, Spriņģe et al.

    Unveiling the Immune Landscape of COVID-19 and prolonged Long-COVID through Single-Cell RNA Sequencing Marta Līva Spriņģe; Kristīne Vaivode; Rihards Saksis; Nineļa Miriama Vainšeļbauma; Laura Ansone; Monta Brīvība; Helvijs Niedra; Vita Rovite Long-COVID affects at least 10% of COVID-19...
  6. John Mac

    Cell-autonomous innate immunity by proteasome-derived defence peptides, 2025, Merbl et al

    Abstract For decades, antigen presentation on major histocompatibility complex class I for T cell-mediated immunity has been considered the primary function of proteasome-derived peptides1,2. However, whether the products of proteasomal degradation play additional parts in mounting immune...
  7. SNT Gatchaman

    Dysrupted microbial tryptophan metabolism associates with SARS-CoV-2 acute inflammatory responses and long COVID, 2024, Yao et al.

    Dysrupted microbial tryptophan metabolism associates with SARS-CoV-2 acute inflammatory responses and long COVID Lu Yao; Hannah Devotta; Junhui Li; Nonhlanhla Lunjani; Corinna Sadlier; Aonghus Lavelle; Werner C. Albrich; Jens Walter; Paul W. O’Toole; Liam O’Mahony Protection against severe...
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    • gut microbiome il-10 il-22 innate immune system interferon-stimulated genes saa sting tlr-3 tlr-4 tryptophan
    • Replies: 1
    • Forum: Long Covid research
  8. SNT Gatchaman

    Peptides from non-immune proteins target infections through antimicrobial and immunomodulatory properties, 2024, Torres et al.

    Peptides from non-immune proteins target infections through antimicrobial and immunomodulatory properties Marcelo D.T. Torres; Angela Cesaro; Cesar de la Fuente-Nunez Encrypted peptides (EPs) have been recently described as a new class of antimicrobial molecules. They have been found in...
  9. SNT Gatchaman

    Immune exhaustion in ME/CFS and long COVID, 2024, Eaton-Fitch et al.

    Immune exhaustion in ME/CFS and long COVID Natalie Eaton-Fitch; Penny Rudd; Teagan Er; Livia Hool; Lara Herrero; Sonya Marshall-Gradisnik Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID are debilitating multisystemic conditions sharing similarities in immune...
    • SNT Gatchaman
    • Thread
    • eaton-fitch hla hla-dqb1 ighg immune dysregulation innate immune system interferon kir marshall-gradisnik ncned
    • Replies: 12
    • Forum: ME/CFS research
  10. SNT Gatchaman

    Monocyte-Mediated Thrombosis Linked to Circulating Tissue Factor and Immune Paralysis in COVID-19, 2024, Goonewardena et al.

    Monocyte-Mediated Thrombosis Linked to Circulating Tissue Factor and Immune Paralysis in COVID-19 Sascha N. Goonewardena; Qinzhong Chen; Ashley M. Tate; Olga G. Grushko; Dilna Damodaran; Pennelope K. Blakely; Salim S. Hayek; David J. Pinsky; Robert S. Rosenson BACKGROUND SARS-CoV-2 infections...
  11. R

    "CFS" and fibro "after" sarcoidosis

    Numerous people are being diagnosed as having CFS and fibro after apparent remission of sarcoidosis. Numerous questions arise 1) What does the diagnoser know about CFS or fibro? 2) What does the diagnoser know about work on post sarcoid fatigue vs sarcoid e.g. persistent shift to TH1 in post...
  12. SNT Gatchaman

    Review Cellular and Molecular Effects of Microgravity on the Immune System: A Focus on Bioactive Lipids, 2024, Fava et al.

    Cellular and Molecular Effects of Microgravity on the Immune System: A Focus on Bioactive Lipids Fava, Marina; De Dominicis, Noemi; Forte, Giulia; Bari, Monica; Leuti, Alessandro; Maccarrone, Mauro Microgravity is one of the main stressors that astronauts are exposed to during space missions...
  13. SNT Gatchaman

    Review SARS-CoV-2 Mitochondrial Metabolic and Epigenomic Reprogramming in COVID-19, 2024, Guarnieri et al.

    SARS-CoV-2 Mitochondrial Metabolic and Epigenomic Reprogramming in COVID-19 Guarnieri; Haltom; Albrecht; Lie; Olali; Widjaja; Ranshing; Angelin; Murdock; Wallace To determine the effects of SARS-CoV-2 infection on cellular metabolism, we conducted an exhaustive survey of the cellular metabolic...
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    • atf6 cgas-sting epigenetics fgf21 gdf15 glycolysis hif-1 histone innate immune system integrated stress response interferon metabolic reprogramming metabolism mitochondria oxidative phosphorylation pentose phospate pathway perk tlr-9 upr
    • Replies: 2
    • Forum: Long Covid research
  14. SNT Gatchaman

    APOE4/4 is linked to damaging lipid droplets in Alzheimer’s disease microglia, 2024, Haney et al.

    APOE4/4 is linked to damaging lipid droplets in Alzheimer’s disease microglia Haney, Michael S.; Pálovics, Róbert; Munson, Christy Nicole; Long, Chris; Johansson, Patrik K.; Yip, Oscar; Dong, Wentao; Rawat, Eshaan; West, Elizabeth; Schlachetzki, Johannes C. M.; Tsai, Andy; Guldner, Ian Hunter...
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    • alzheimers amyloid amyloid plaque apoe genetic innate immune system lipid droplets lipids microglia neurodegenerative disease risk factors
    • Replies: 0
    • Forum: Other health news and research
  15. SNT Gatchaman

    Review Rethinking coagulation: from enzymatic cascade and cell-based reactions to a convergent model involving innate immune activation, 2023, Yong, Jun and

    Rethinking coagulation: from enzymatic cascade and cell-based reactions to a convergent model involving innate immune activation Yong, Jun; Toh, Cheng-Hock Advancements in the conceptual thinking of hemostasis and thrombosis have been catalyzed by major developments within health research over...
  16. SNT Gatchaman

    Review Systems analysis of innate and adaptive immunity in Long COVID, 2024, Peluso et al.

    Systems analysis of innate and adaptive immunity in Long COVID Peluso; Abdel-Mohsen; Henrich; Roan Since the onset of the COVID-19 pandemic, significant progress has been made in developing effective preventive and therapeutic strategies against severe acute SARS-CoV-2 infection. However, the...
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    • b cells immune system immunoglobulin innate immune system long covid system biology t cells
    • Replies: 2
    • Forum: Long Covid research
  17. SNT Gatchaman

    Review Defining trained immunity and its role in health and disease, 2020, Netea et al.

    Defining trained immunity and its role in health and disease Netea, Mihai G.; Domínguez-Andrés, Jorge; Barreiro, Luis B.; Chavakis, Triantafyllos; Divangahi, Maziar; Fuchs, Elaine; Joosten, Leo A. B.; van der Meer, Jos W. M.; Mhlanga, Musa M.; Mulder, Willem J. M.; Riksen, Niels P.; Schlitzer...
  18. SNT Gatchaman

    Review Functional Reciprocity of Amyloids & Antimicrobial Peptides: Rethinking the Role of Supramolecular Assembly in Host Defense, Immune Activation…, 2020

    Functional Reciprocity of Amyloids and Antimicrobial Peptides: Rethinking the Role of Supramolecular Assembly in Host Defense, Immune Activation, and Inflammation Lee EY; Srinivasan Y; de Anda J; Nicastro LK; Tükel Ç; Wong GCL; Pathological self-assembly is a concept that is classically...
  19. rvallee

    Evolution of enhanced innate immune suppression by SARS-CoV-2 Omicron subvariants, 2024, Towers et al

    Evolution of enhanced innate immune suppression by SARS-CoV-2 Omicron subvariants Nature, open access: https://www.nature.com/articles/s41564-023-01588-4 Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) human adaptation resulted in distinct lineages with enhanced...
  20. SNT Gatchaman

    Preprint Transcriptional memory is conferred by combined heritable maintenance and local removal of selective chromatin modifications, 2023, Mikulski et al.

    Transcriptional memory is conferred by combined heritable maintenance and local removal of selective chromatin modifications Pawel Mikulski; Sahar S.H. Tehrani; Anna Kogan; Izma Abdul-Zani; Emer Shell; Brent J Ryan; Lars E.T. Jansen Interferon-γ (IFNγ) transiently activates genes involved in...
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