The biology of coronavirus COVID-19 - including research and treatments

You can't ethically expose people to Covid so they just had to give people the real or placebo vaccine and let them live their lives.

 

Well, if Pfizer says it...it MUST be true?

 

Vaccine Efficacy is usually between 40%-60%. It's inconsistent and contradictory for Pfizer to illegally leak that their Covid vaccine is 90% based off manipulated facts from a trial.

 

My sentiments entirely Mij, I'm not anti-vax by any stretch of the imagination, but anyone who just takes their word for it is a bit naive iyam. It will need to be seriously scrutinised. I hope that need for scrutiny & interrogation of the rsearch will not be lost in the relief and urgent longing for a vaccine to 'save us' & save our way of life.

 

Wish all the mink farms in this world would just "cull" their pelts a tad early and euthanize the beasts.

Great deal of infection with SARS CoVi-2 virus in minks, and risk for mutations making the upcoming vaccines less effective.

 

But how do they know if the two groups of people had the same exposure to the virus? Are their assumptions on this valid?

 

Interesting how the CEO took this route before the vaccine goes any further in development as well:

 

This could mean that he expects enthusiasm for the vaccine to decline soon, for whatever reason.

 

They would randomise them to either the placebo or active vaccine arm and the randomisation ought to have delivered equalish exposure to the virus.

 

They don't know. They just hope their randomisation wasn't biased in any way.

 

I'm wondering if someone could update me on current thinking about routes of transmission into the body, and whether it's still believed that the eyes are a possible route, or whether it's since been decided that it's really only mouth and nose? If the latter, it would be nice to be able to rub my eyes again ...

 

SSRI potential early COVID treatment

https://www.s4me.info/threads/fluvo...d-clinical-trial-lenze-et-al-jama-2020.17777/

 

Yea I guess the numbers are fairly big (23K in the control and test groups?) - so the exposure should be similar - I guess. Once they roll it out then it should be fairly clear i.e. the efficacy.

 

Arthritis drug 'cuts elderly Covid-19 deaths by two-thirds'

http://www.msn.com/en-gb/health/med...-deaths-by-two-thirds/ar-BB1b179f?ocid=ASUDHP

 

I can't find any published results of a randomised trial of Barictinib.

The Karolinska trial is just a retrospective analysis:
https://advances.sciencemag.org/content/early/2020/11/13/sciadv.abe4724

There were three previous non-randomised studies discussed in this review:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457585/

 

So that's now allegedly two vaccines we have which sound as though they might be viable - and the new one doesn't need to be deep-frozen, which is good. But I still don't understand how researchers can be so sure they're so effective if they don't know how many of their test subjects have actually been exposed to the virus ...

 

The "deep freeze" is slightly exaggerated, mRNA vaccines don't have to be quite that cold.

But the choice between the vaccines shouldn't be based on whether one has to be deep frozen or not, it should be on the basis of the best safety vs efficacy record. By that measure, the adenovirus vector vaccines come in second place.

Also, don't put too much stock into these 90% "efficacy" claims as these claims are more marketing than evidence based - with the Astrazeneca vaccine being even more heavily promoted to governments than the others.

 

They judge exposure by how many of the placebo people got the virus.

 

I'm planning to listen to the Radio 4 programmes How to vaccinate the world [https://www.bbc.co.uk/programmes/m000py6s/episodes/player]

The presenter (Tim Hartford) was interviewed on BBC2 - Newsnight last night. I think one of his replies, re how long immunity would last, was - we'll just have to wait and see.

So far the sample size is small and the claim that the Modena (?) vaccine resulted in no serious cases of Covid is based on very limited data.

Yea the Modena vaccine is stored at -20 (home freezer) and then fridge for days (5 ish?). Even the Pfizer vaccine can be stored for days (5 ish?) in a fridge.

I'm interested in @Snow Leopard comments re adenovirus-based vaccines - can they be delivered in the short/medium term?