The biology of coronavirus COVID-19 - including research and treatments

Snow Leopard said:
Most proteases like this are weak antivirals at best, generally used to enhance a primary therapy.
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Thank you @Snow Leopard for your comments re the above antiviral.

Do you have any comments on the TB vaccine study, with link below?

Thank you very much for your replies.

DokaGirl said:
"Healthcare workers trial TB vaccine for coronavirus protection"
https://www1.racgp.org.au/newsgp/clinical/healthcare-workers-to-trial-tuberculosis-vaccine-f
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Some posts moved from the Worldwide spread and control thread
Mij said:
I have read that Wuhan residents who had tested positive earlier and then recovered from the disease are testing positive for the virus a second time. Based on data from several quarantine facilities in the city, which house patients for further observation after their discharge from hospitals, about 5%-10% of patients pronounced "recovered" have tested positive again.

Is this what they are referring to by 'second wave'? I'm so confused from all the conflicting information out there.
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Could this be a virus that becomes dormant in someone, rather than eradicated, and then reactivates again?
 
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@Barry COVID19 is an enveloped RNA virus.

These small, enveloped RNA viruses replicate via reverse transcription of their RNA genomes; the resulting DNA establishes persistence by integrating into the host genome, from which it generally cannot be dislodged. In most infected cells in culture, such integrants continue to express genomic RNA and viral proteins, leading to the production of progeny virions. However, in some cultured cells such integrants are completely transcriptionally silent, though they can be exogenously stimulated to express viral mRNAs and resume virus production. These cells meet the molecular definition of latency.
 
Mij said:
@Barry COVID19 is an enveloped RNA virus.

These small, enveloped RNA viruses replicate via reverse transcription of their RNA genomes; the resulting DNA establishes persistence by integrating into the host genome, from which it generally cannot be dislodged. In most infected cells in culture, such integrants continue to express genomic RNA and viral proteins, leading to the production of progeny virions. However, in some cultured cells such integrants are completely transcriptionally silent, though they can be exogenously stimulated to express viral mRNAs and resume virus production. These cells meet the molecular definition of latency.
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Er ... thank you @Mij ... although I understand about 90% of the words, the missing 10% and the way the 90% go together ... means I don't have a clue what you are trying to explain to me :confused:. Thank you, but it's way over my head :).
 
DokaGirl said:
Do you have any comments on the TB vaccine study, with link below?
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They seem to be aiming for non-specific immune stimulation, it looks like they're scraping the barrel. The problem is that even if has an effect, it will only make a small difference.

There was no cross reactivity of antibodies to childhood vaccines (including BCG) towards SARS-1.0 (note: in mice)
https://jcp.bmj.com/content/60/2/208.full
 
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Trish said:
Can you link the source of this? I have seen rumours, but the ones I saw turned out to be contamination from the owners on the test, I think.
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There's this from ProMED mail today, and beneath is a list of other mails concerning dogs and cats. From what I recall about the 2 dogs concerned the first one was probably just picking up the virus environmentally. The second one got ill though, but I can't find the mail about that one right now. It's probably somewhere in that list of mails.

Here's the one about the cat.
 
DokaGirl said:
"UBC-led study finds trial drug can significantly block early stages of COVID-19 in engineered human tissues"

https://www.med.ubc.ca/news/ubc-led...ages-of-covid-19-in-engineered-human-tissues/

@Snow Leopard @Mij
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How are they administering this? It needs to be in the respiratory membranes, not in the blood. The therapy would rely on steric effects, namely coating the spike proteins on the virus with the soluble ACE2, so that the virus cannot use these receptors to bind to the cell.

It might work, I have no idea whether it would cause significant side effects though.
 
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