The Atlantic: A Breakthrough in the Mystery of Why Women Get So Many Autoimmune Diseases

[ME/CFS Skeptic]

The main idea of the theory proposed is that in pre-modern times women were pregnant a lot of the time and the placenta was signaling the immune system to be chill. Now that women get pregnant much less, there is no longer that feedback from placentas that kept the immune system in check and that is believed to be the cause why women get so many autoimmune diseases. According to this hypothesis, women who had a lot of babies should have less auto-immune diseases.

Full article: https://www.theatlantic.com/health/archive/2019/06/women-autoimmune-diseases-pregnancy/591901/

I'm posting this because one of the few robust findings in the field of ME/CFS is that women tend to have the illness more often than men.

 

[andypants]

How does that fit with the fact that a lot of women develop autoimmune disease and ME from pregnancy/childbirth?

Also, haven’t women always had more of these issues, even if the frequency might be higher now (which I have yet to see any convincing evidence of)?

Not buying it.

 

[Jonathan Edwards]

The theory is based on a common misconception - that the placenta and fetes are 'foreign' and should be rejected like a foreign graft.

This is one of the most persistent myths in immunology but it does not work, for the simple reason that the mother and the placenta each have their own separate circulatory system. A skin graft is rejected because it is applied by the host circulation with host immune cells, that return to host lymph nodes and activate more host cells to return to the graft. But a placenta is supplied by the foetus's circulation and the foetus's cells which return to the foetus's lymph nodes and find nothing foreign for the foetus.

The only immune reaction that you get in pregnancy is a maternal reaction against stray foetal red cells that get into the mother's circulation and stimulate antibodies that can then get into the foetus and cause rhesus disease (neonatal haemolytic anaemia).

We live in a world of Chinese whispers.

 

[Mithriel]

What the implications are I don't know but I have read that they find DNA from all your children in your blood.
The science of genetics is immensely more complicated than anyone expected and will take a long time to unravel.

The way one x chromosome is inactivated at random in every cell of a woman may even have consequences.

Biology is so complex and interesting it is a source of endless fascination - one reason why I get so angry at the facile explanations of the BPS crowd.

 

[Jaybee00]

I will write an email to the author--is it OK if I cc you @Jonathan Edwards--thanks.

 

[wingate]

I think I'll wait to see some data before spending much more time thinking about this theory...

I liked this quote from Dr. Hafler: “Ideas are cheap. It’s data which is hard to get.”

I do appreciate Olga Khazan's writing about ME. Many probably read her 2015 article: https://www.theatlantic.com/health/...gue-patients-push-for-an-elusive-cure/409534/

I wish she would do an update...

 

[Jaybee00]

Thanks—I think I remember that one...

 

[Alvin]

Its a theory that can be "confirmed" with confirmation bias.
And this theory will be used as rationalization for treating women as baby incubators