1. Guest, the two part 'News in Brief' for the week beginning 15th November 2021 is here.
    Dismiss Notice
  2. Welcome! To read the Core Purpose and Values of our forum, click here.
    Dismiss Notice

Open Sweden: ME/CFS lactate, glucose and hypoxanthine

Discussion in 'Recruitment into current ME/CFS research studies' started by mango, Jul 27, 2021.

  1. mango

    mango Senior Member (Voting Rights)

    Messages:
    1,654
    An ad is currently being circulated in Swedish ME groups on social media, a research study led by prof Jonas Bergquist at Uppsala University that is currently recruiting.

    It's a study on altered energy metabolism in ME/CFS, focusing mainly on lactate, glucose and hypoxanthine.

    (I couldn't find any info about this study on the ME/CFS Collaborative Research Center at Uppsala University's website, nor on the OMF website's page on Uppsala's research that it redirects to.)

    They are inviting people mainly in Västa Götaland region, who have been diagnosed with ME/CFS according to the Canadian consensus criteria, and healthy controls too.

    They are offering home visits for the tests (blood tests + light physical & mental exertion challenge).

     

    Attached Files:

    Last edited: Jul 28, 2021
    alktipping, rainy, inox and 17 others like this.
  2. mango

    mango Senior Member (Voting Rights)

    Messages:
    1,654
    I have received copies of all the documents from the Ethical Review Authority now, too :) Too many, too large to upload them all here, but feel free to ask if you want more details on something.

    Ethical approval was obtained on 21 July 2021.

    Other people involved in this project are: professor emeritus Ola Saugstad, Oslo, Norway (advisor) and Anders Tageson, MD (responsible for collecting the samples).
     
    Last edited: Jul 27, 2021
    alktipping, inox, Anna H and 6 others like this.
  3. mango

    mango Senior Member (Voting Rights)

    Messages:
    1,654
    Some auto-translated bits:
    Original project title: Förändringar av laktat, glukos och hypoxantinnivåer i blod från patienter med myalgisk encefalomyelit (ME) under mental och lätt fysisk ansträngning.
     
    alktipping, Anna H, Ravn and 7 others like this.
  4. Grigor

    Grigor Senior Member (Voting Rights)

    Messages:
    344
    Interesting. Thank you for sharing! Had never heard of hypoxanthine. Had it ever been tested in relation to ME?
     
    alktipping, Anna H, MeSci and 3 others like this.
  5. mango

    mango Senior Member (Voting Rights)

    Messages:
    1,654
    I don't know if it has been researched in relation to ME before. Here's what the Background section in the ethics application says:
     
    Last edited: Jul 28, 2021
    Hutan, alktipping, J.G and 7 others like this.
  6. Grigor

    Grigor Senior Member (Voting Rights)

    Messages:
    344
    Thank you! Very interesting and I'm looking forward to the results.
     
    Hutan, alktipping, Anna H and 5 others like this.
  7. Andy

    Andy Committee Member (& Outreach when energy allows)

    Messages:
    14,739
    Location:
    Hampshire, UK
    Hutan, alktipping, Michelle and 8 others like this.
  8. mango

    mango Senior Member (Voting Rights)

    Messages:
    1,654
    From the Overview section of the ethics application:
     
    alktipping, Anna H, Trish and 4 others like this.
  9. Grigor

    Grigor Senior Member (Voting Rights)

    Messages:
    344
    alktipping, Anna H, MeSci and 4 others like this.
  10. Ravn

    Ravn Senior Member (Voting Rights)

    Messages:
    1,459
    The inclusion of elite athletes as controls is interesting. I wonder why they didn't also include sedentary healthy controls?
     
    alktipping, Anna H, Grigor and 4 others like this.
  11. Andy

    Andy Committee Member (& Outreach when energy allows)

    Messages:
    14,739
    Location:
    Hampshire, UK
    Hutan, alktipping, J.G and 8 others like this.
  12. Marky

    Marky Senior Member (Voting Rights)

    Messages:
    570
    Location:
    Norway
    Interesting, I just found out via test that I have low xanthine. is that the same as hypoxanthine?
     
    Ravn, Hutan, alktipping and 1 other person like this.
  13. Marky

    Marky Senior Member (Voting Rights)

    Messages:
    570
    Location:
    Norway
    Maybe because we ME-patients work out metabolically all day he he
     
    Ravn, alktipping and Peter Trewhitt like this.
  14. Kitty

    Kitty Senior Member (Voting Rights)

    Messages:
    2,458
    Location:
    UK
    There was talk in the 90s about ME patients being in a sense comparable to highly trained athletes, in that both groups are functioning at the limits of their endurance.

    I don't know whether that comparison is meaningful or not, though.
     
    MeSci, Ravn, Peter Trewhitt and 2 others like this.
  15. Hutan

    Hutan Moderator Staff Member

    Messages:
    17,349
    Location:
    New Zealand
    So, the hypothesis is that hypoxanthine is increased.

    The McGregor study associated lower hypoxanthine with PEM.

    And Andy tells us this one found lower hypoxanthine in pwME.

    It's interesting. Hopefully the study will tell us more. Possibly it will take some careful stratification of participants, including determining whether they are in PEM or not.
     
  16. Ravn

    Ravn Senior Member (Voting Rights)

    Messages:
    1,459
    Peter Trewhitt and Hutan like this.
  17. mango

    mango Senior Member (Voting Rights)

    Messages:
    1,654
    Irina66, Peter Trewhitt and Hutan like this.

Share This Page