Preprint Spironolactone for ME/CFS in a Patient Homozygous for rs5522 (I180V): A Case Report, 2026, Donnellan et al

[jnmaciuch]

Other preprint including the same author on rs5522:
Comparison of transcriptional activation by corticosteroids of human MR (Ile-180) and haplotype (Val-180)

I linked it earlier in the thread, it looks like the original version did not include this thread's author (and did not include reference to ME/CFS)

 

[jnmaciuch]

I want everyone to feel better.

Honestly, I’m gotten some online harassment since the pre print so if I seem short, I’ve just been through some “ people “ getting really pissy about what I put out in the world. I read every reference throughly.

Sorry to hear you've been experiencing that. We all want people with ME/CFS to get effective treatments too. On this forum we go through papers in-depth, which is why we are interested in the details. We'd be very interested to know the raw data and your process for determining that you had the Ile180Val mutation

 

[Utsikt]

I linked it earlier in the thread, it looks like the original version did not include this thread's author (and did not include reference to ME/CFS)

The only reference to ME/CFS is in relation to the case report from this thread.

There is a claim about how «hyperactivity mediated by brain rs5522» «contributes to ME/CFS», but no evidence is provided in the paper.

Aldosterone [32, 33] and cortisol [33, 38] are transcriptional activators of MR rs5522. However, EC50s and fold-activation by aldosterone, corticosterone and 11-deoxycorticosterone for the rs5522 haplotype have not been reported, which is our goal. Activation of rs5522 by a corticosteroid other than cortisol could provide clues to the unique physiological actions mediated by rs5522 in the brain MR.

Nor has the binding of spironolactone and progesterone, two MR antagonists [39, 40] to rs5522 been investigated. Inhibition of brain rs5522 would provide a selective method for treating hyperactivity mediated by brain rs5522, which contributes to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

 

[leokitten]

rs5522 SNP

A allele = Codes for ISOLEUCINE (Ile, I) at position 180

G allele = Codes for VALINE (Val, V) at position 180

23andMe rs5522

23andMe notation terms:

They report opposite strand

A/G (forward strand) = T/C (reverse strand)

TT = GG on forward strand

Sorry but the end there is not correct, 23andme TT = AA on the forward strand