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Scientists provide new insights into the citric acid cycle

Discussion in 'Other health news and research' started by Mij, Oct 23, 2021.

  1. Mij

    Mij Senior Member (Voting Rights)

    Researchers have new insights into the citric acid cycle: Certain bacteria can use this central metabolic pathway 'backwards', but to do so they must have very high concentrations of the enzyme citrate synthase and of carbon dioxide. This pathway may be a relic from the early development of life.

    The team studied the anaerobic bacteria Hippea maritima and Desulfurella acetivorans.

    The "backward cycle" that uses citrate synthase for citrate cleavage cannot be bioinformatically predicted, as it does not have the key enzymes whose presence can be used as a marker for the functioning of the pathway. Therefore, as an identifying feature for bioinformatic analyzes, the scientists used the detected high levels of citrate synthase in these bacteria's protein cocktail. Using a special analysis tool, the researchers were able to predict the production levels of individual proteins. With this trick, it was possible to predict the functioning of the "backward cycle" for inorganic carbon fixation in many anaerobic bacteria.

    sebaaa, Ron, DokaGirl and 6 others like this.
  2. Jonathan Edwards

    Jonathan Edwards Senior Member (Voting Rights)

    London, UK
    Maybe with global warming levels of Co2 will b e so high that life will go backwards.
    Perhaps we can look forward to dinosaurs vlove-ing again and dodos strutting across the croquet lawn.
    sebaaa, DokaGirl, FMMM1 and 8 others like this.
  3. Mij

    Mij Senior Member (Voting Rights)

    Will global warming reverse my citric acid cycle? It's kind of stuck right now.
    DokaGirl, Milo, alktipping and 3 others like this.
  4. alktipping

    alktipping Senior Member (Voting Rights)

    if their is a new species of dodo to come then people will finally get free lunches .that is until they become extinct again .
    Peter Trewhitt, DokaGirl and Mij like this.
  5. Milo

    Milo Senior Member (Voting Rights)

    Ah, now i get it that ME is deemed an environmental illness in Ontario
    DokaGirl, Mij, alktipping and 2 others like this.
  6. DokaGirl

    DokaGirl Senior Member (Voting Rights)

    alktipping and Mij like this.

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