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Scientific Advances in and Clinical Approaches to Small-Fiber Polyneuropathy (2019) Oaklander et al

Discussion in 'BioMedical ME/CFS Research' started by strategist, Sep 9, 2019.

  1. strategist

    strategist Senior Member (Voting Rights)

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    A review of small-fiber polyneuropathy. Interestingly, it says that evidence suggests it contributes to PEM.

    https://jamanetwork.com/journals/jamaneurology/article-abstract/2749401

     
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  2. wigglethemouse

    wigglethemouse Senior Member (Voting Rights)

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  3. DokaGirl

    DokaGirl Senior Member (Voting Rights)

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    Do you know what a high B6 level would be?

    I didn't see a specific bench mark noted in the NIH articles below; of course this would depend on age, gender, size etc.


    About B6 from Medline Plus - NIH - U.S. National Library of Medicine: https://medlineplus.gov/druginfo/natural/934.html#Dosage

    "What dose is used?
    The following doses have been studied in scientific research:

    ADULTS

    BY MOUTH

    ......

    • For vitamin B6 deficiency: In most adults, the typical dose is 2.5-25 mg daily for three weeks then 1.5-2.5 mg per day thereafter. In women taking birth control pills, the dose is 25-30 mg per day....."
    There are several health conditions listed, and recommended doses for each.

    Odd, I can't find the RDA in this article, except for as noted above for deficiency.

    Another NIH article has the RDA for various stages of life:

    https://ods.od.nih.gov/factsheets/VitaminB6-Consumer/
     
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  4. wigglethemouse

    wigglethemouse Senior Member (Voting Rights)

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    According to LabCorp this is the reference range for normal levels
    Male: 5.3-46.7 µg/L; female: 2.0-32.8 µg/L
    https://www.labcorp.com/test-menu/36686/vitamin-bsub6-sub-plasma

    Even a small amount of supplementation every other day took my blood levels above the high level which would be bad for small fiber neuropathy. I wish I had never taken it - At the time I was left with the impression that vitamins were harmless and any excess would not be absorbed by the body.
     
  5. DokaGirl

    DokaGirl Senior Member (Voting Rights)

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    @wigglethemouse

    Thank you. I've seen B6 in a 250 mg strength, as just a run of the mill supplement. This level is certainly over the RDA.
     
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  6. wigglethemouse

    wigglethemouse Senior Member (Voting Rights)

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    I used to take this - Natures Bounty B Complex from Amazon. Vitamin B6 content 5mg, 294% % daily value. I used to take half a pill every other day and that was too much based on blood testing.
    [​IMG]
     
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  7. ProudActivist

    ProudActivist Senior Member (Voting Rights)

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    I have supplemented with B6 on and off because it’s recommended for minimising menstrual issues. I also have taken half tablets due to the dose of all the contents being so high it seems ridiculous.
     
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