Ronald W. Davis, PhD's presentation at the IIMEC13

I just got this e-mail from OMF, its a video about 1 hour 2 minutes long

 

Looking through a different perspective what Dr Davis discussed :




Trypanosomes and Liver Disease :

https://www.ncbi.nlm.nih.gov/pubmed/27693222


Low Selenium :

Link : https://www.ncbi.nlm.nih.gov/pubmed/1500682

Status of Trace Minerals in Liver Disease :

Link : http://www.medsci.org/v10p0730.htm


From my presentation in EUROMENE, Slide 10 mentioned how Zinc supplementation has helped my Symptoms :





Slide 39, the consequences of Viral Infection on Liver function : Reading the annotated text we see Alterations in Bile Secretion, Gluconeogenesis, Glycolysis, Detoxification and Balance of Nutrients :






I Hypothesise that ME/CFS patients do not have a Viral Infection. A Liver Injury (from Viral Infection, some medications and even prolonged stress) along with an unfortunate combination of problems in Phagocytosis, ER Stress, Vitamin K Metabolism and Inflammatory Processes results in a vicious cycle of Inflammation, Oxidative Stress and Autoimmunity with several negative implications.

 

I'd be interested in some kind of transcript or write up if one becomes available? I'm not really up for watching such a long presentation.

 

I just finished watching it and the narrator makes a good point but more specifically he is saying that a watershed moment opened up money for brain cancer so we need to either create one or convince those holding the purse strings to open them.

 

It's interesting that both Ron Davis and Nancy Klimas think that ME is a "metabolic trap" that should turn out to be fairly easy to "escape" once it's understood. Are they working together on this idea, or have they just come to this conclusion independently?

Along the same lines, has anyone heard anything about Dr. Klimas' current GWI study? A similar intervention in a few ME patients was supposed to have begun in "early 2018," but that's the last I heard of it.

 

I'm not a fan of this view. I think its an over simplistic framework that many things could (will) be shoehorned into but is basically a mold that is an abstraction. Not sure if that is making much sense.

 

I Second that.

Unfortunately i do not agree with Dr Davis's comment that in a few days with one pill everything will be over (if this theory is right)

 

He may be right, or it may be a symptomatic treatment or it may be a "reset" pill whenever a patient relapses (since most patients were not born with ME/CFS and lived many years before something triggered it).

I don't agree with the theory you posted above and in the other thread, i suspect ME is an immune mediated disease, something sets off the cascade and it ratchets down energy production. The long term ratcheting down is caused by PEM/anaerobic activity or autoimmunity for some or some other method such as everyday immune activities (our immune systems are working every second of every day to keep us alive). The reason for ratcheting down is likely a bit different for each patient, if its B cell autoimmune then Rituximab may be the proper treatment, if its viral load then antivirals may be the right treatment for that patient. But whats causing it may be a few fold so each type would require its proper treatment yet i suspect they are all leading to Rome, a few different causes making the immune system to go down the same maladaptive path. This would also explain why various researchers including Dr Davis have found the same dysfunctions in all patients while some respond to Rituximab (something being investigated by Dr Scheibenbogen), because the cause may be a few different ones but the cascade beyond trigger is the same with the caveat that some might have a trigger that has long gone while some have a trigger that remains in the body which can be treated.

Hence its likely to be some form of protective mechanism gone wrong, our immune system does lower our activity level when fighting colds and other large infections, but ME is likely a constant state that keeps getting stronger and making us worse.

But i do agree that its probably treatable if we could understand the disease mechanism and hit it with some drug, some patients are relapsing/remitting and some experience dramatic improvements spontaneously. Why is the million dollar question.

 

And some are probably like me, with dramatic improvements early on, for half a day or more, then a change in diet brings about considerable improvement for up to one or two years, then relapse again. Then a different (blood pressure) drug brings about considerable improvement but some reduction in energy for one or two years, then new problems arise...

What if the 'new discovery' only works for a year or two?

(At least with all the work that's going on they might know why.)

 

Trish,

I do understand your point of view. Unfortunately i am not good with words -i can definitely say this- and what i tried was putting my point of view that i find the metabolic trap hypothesis simplistic. I do not have the capacity and did not in any way suggested that there is no point in looking at all of this. Dr Davis presented several findings and as i mentioned in my post i looked through a different perspective his talk.

I hope this clears any misunderstanding.

 

To a point i agree, my theory was a response to another theory which was not part of the original thread intent or content.

This is why i hate accidental unexplained discoveries. When you don't know whats going on the results are unpredictable which drives me bonkers.
That said i love accidental but explained discoveries

 

This goes along with Dr. Paul Cheney's theory- 'protective mechanism'.

 

Until any scientific expert proves otherwise, I am going to continue to believe that ME is a particular condition brought down upon people who thought they could think through things just to prove that they can't. Indirectly it supports the hypothesis that we are all still in the Matrix.

 

But if we were living in the Matrix, would the Matrix allow the movie "The Matrix" to be made, thus making people suspicious that they might be in the Matrix? Would I even be allowed to write this post to discuss... wait a minute - there's a knock at the door.

 

44:48 mins Metabolic Trap:
What they think is happening (best guess at the moment), is because of the genetics and inflammation that gets started is that you can get yourself
in a situation where your pathways which are normally supposed to work, get altered because of the mutations and metabolites and
enyzamatic process gets trapped into a non functional state. When he says trapped, there is no easy way out.
So what this would predict, is that something would trigger it (an infection), it would change your metabolism to the point where it
gets trapped. That would happen almost instantaneous, you would go to sleep and wake up with the disease.
and nothing you do will get you out of it, there will be no drugs to get you out of it. The good news is that by understanding what
it is if this is all true, it will probably be very easy to fix. But it won't be something anybody's tried. They'll have to manipulate the
metabolism, but, it should be very inexpensive to do it and should take you a few days to get out of it."

 

Is my understanding correct that despite the extensive testing that was performed to ME/CFS Patients, no virus has been found?

Also, Dr Davis suggests that this may be a virus that we are not aware of?

 

Re the autism expression overlap. Theory in tweet link is on combinations of mutations, not just one
https://www.medicalnewstoday.com/articles/amp/323035?__twitter_impression=true

 

Sleeping sickness only manifests once the trypanosomes cross the blood-brain barrier. Once they do so, the trypanosomes apparently induce sleeping sickness as a consequence of their manufacture of the molecule tryptophol.

There's something else in the body that can produce tryptophol, though - the yeast Candida albicans. The overgrowth of C. albicans in the gut has been proposed as a cause of CFS since the mid-1980's, but the proposed mechanism has been via the yeast's production of acetaldehyde - a molecule also produced in the liver during the breakdown of alcohol. Acetaldehyde is thought to mediate hangover symptoms, which led some to believe that it was connected to CFS symptoms like light and sound sensitivity.

I don't know if excessive tryptophol produced by C. albicans overgrowth in the gut could make its way from the gut to the brain and cross the blood-brain barrier, but I have often wondered if ME/CFS might not be a form of "poisoning" via some seemingly normal process run amok.