Rituximab and placebo response

Marky said:
Well.. Im pretty sure I cant get a placebo with this. I took Rituximab with no placebo also, and my symptoms dont go away momentarily even if I believe in a treatment. Apparantly a lot of ME-patients can though, it puzzles me. Im not sitting on a high horse saying that, just saying I dont get it from my own experience.
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Ah now @Marky. That would be the nocebo* effect. Deep, deep down in your heart you were worried Ritux wasn't going to work - so of course it didn't.

*Nocebo: defined as punishment for cynical souls who refuse to believe in magic, consciously or subconsciously. Expect a publication in a prestigious journal anytime soon.**

** There probably already is but I haven't the stomach to look.
 
Marky said:
And by the way small things like this, can influence function level questionnaires heavily, if u answer before exerting yourself
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Yes exactly, I always wondered why they didn’t use some type of more quantitative physical exertion test for the primary endpoint. Ampligen did for their trial, though not sure if there were criticisms of their specific choice of test.
 
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Ravn said:
** There probably already is but I haven't the stomach to look.
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That's your cynical soul right there :whistle:

How much do we have to exert ourselves to say something is not working good enough (if it is working at all)? I miss doing heavy workouts and hiking tall mountains, but I would still be interested in something that allows the "exertion" of daily living to not be a problem on bad days even if I can't do the more strenuous things.
 
Midnattsol said:
That's your cynical soul right there :whistle:

How much do we have to exert ourselves to say something is not working good enough (if it is working at all)? I miss doing heavy workouts and hiking tall mountains, but I would still be interested in something that allows the "exertion" of daily living to not be a problem on bad days even if I can't do the more strenuous things.
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It varies greatly between ME-patients.. In my first year i would get bad PEM from running, or lifting weights for 30 mins. Last year I got bad PEM from trying to make dinner.
 
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