Kalliope
Senior Member (Voting Rights)
Provisionally accepted opinion article in frontiers in Pediatrics - Paediatric Neurology
Review of the Quality Control Checks Performed by Current Genome-Wide and Targeted-Genome Association Studies on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
by Nuno Sepulveda, Anna D. Grabowski, Eliana M. Lacerda and Luis C. Nacul
In summary, given the partial QC checks performed in current GWAS and TGAS, the question of a genetic component in ME/CFS remains open for investigation. To accelerate the discovery of promising disease-gene association, future genetic studies of ME/CFS should set data and methodological standards as high as those followed by the 1000 Human Genome Project and the UK10K project (19,20). Data sharing should also be a general practice to provide the researcher community the opportunity to perform additional checks or alternative analyses of the same data.
Review of the Quality Control Checks Performed by Current Genome-Wide and Targeted-Genome Association Studies on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
by Nuno Sepulveda, Anna D. Grabowski, Eliana M. Lacerda and Luis C. Nacul
In summary, given the partial QC checks performed in current GWAS and TGAS, the question of a genetic component in ME/CFS remains open for investigation. To accelerate the discovery of promising disease-gene association, future genetic studies of ME/CFS should set data and methodological standards as high as those followed by the 1000 Human Genome Project and the UK10K project (19,20). Data sharing should also be a general practice to provide the researcher community the opportunity to perform additional checks or alternative analyses of the same data.
