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Rethinking the treatment of chronic fatigue syndrome—A reanalysis and evaluation of findings from a recent major trial of graded exercise and CBT

Discussion in 'PsychoSocial ME/CFS Research' started by Carolyn Wilshire, Feb 6, 2018.

  1. alex3619

    alex3619 Senior Member (Voting Rights)

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    Its indirect evidence of deliberate bias. Direct evidence occurs with the manipulation of SF36PF data in the calculation of normal, on which their claim of any recovery relies heavily.
     
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  2. alex3619

    alex3619 Senior Member (Voting Rights)

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    Breaking news, new therapy causes recovery in the recently departed. ;)
     
  3. Barry

    Barry Senior Member (Voting Rights)

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    I suppose this is roughly analagous to a taxation law, that is then explained in more detail in a guideline document. The guideline document has no remit to change the law itself.
     
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  4. Clara

    Clara Established Member (Voting Rights)

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    Has it been looked at how many people got worse, and by how much, compared by treatment?

    I have no spreadsheet skills at the moment so have only been able to see from a histogram of all participants that it looks like about 1/3 of participants had negative change in SF-36 physical functioning score and 6 minute walk distance. Would like to see it by trial arm.
     
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  5. Kalliope

    Kalliope Senior Member (Voting Rights)

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    The Journal of the Norwegian Medical Association has written an article about the re-analysis.

    Neurologist and senior doctor at Haukeland university hospital, Jone Furlund Owe, comments on the re-analysis and says it has a weakness in that the authors didn't have all the data from the PACE-trial. He thinks the authors make the same mistake as the PACE-authors when concluding that it is now time to look for other effective treatments for chronic fatigue syndrome. He says the new analysis can't confirm there are no positive effects from CBT or GET, it only points to weaknesses to the PACE-study.

    Jone Furlund Owe is responsible for the ME-assessment at his ward. He is known for a biopsychosocio approach to ME.

    Tidsskrift for den norske legeforening: Tvil om studiefunn ved kronisk utmattelsessyndrom
    google translate: Doubt about study findings in Chronic Fatigue Syndrome
     
    Last edited: Aug 24, 2018
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  6. Kalliope

    Kalliope Senior Member (Voting Rights)

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    Yes it did. Thanks for letting me know! I've corrected the link.
     
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  7. Tom Kindlon

    Tom Kindlon Senior Member (Voting Rights)

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    Last edited: Sep 22, 2018
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  8. Tom Kindlon

    Tom Kindlon Senior Member (Voting Rights)

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  9. Clara

    Clara Established Member (Voting Rights)

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    As if you're supposed to only research one possible treatment until it's been proven there are no positive effects? Then we should have only looked at bloodletting for every disease for the last couple centuries.

    Same mistake? So according to him,

    Time to look for other treatments = Unblinded subjective study with outcome switching, moving the goalpost behind the starting line, publishing testimonials mid-trial, trying to hide data...

    Um no, that's not even comparing apples and oranges, or apples and baboons.

    The "logic" of the biopsychosocial crowd is astounding.

    But thanks for pointing out that not letting others have access to all the PACE trial data creates a weakness for anyone trying to critique PACE.
     
  10. Tom Kindlon

    Tom Kindlon Senior Member (Voting Rights)

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  11. Sbag

    Sbag Senior Member (Voting Rights)

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    This post on the BBC was dated 22 March 2018 but this tweet link today bagged another response from the Prof

    upload_2019-3-22_17-5-16.png
     
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  12. Andy

    Andy Committee Member & Outreach

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    The arrogance of the man demanding that Sean share something of his choosing.

    It doesn't look like Sharpe really wants that article shared, therefore
     
  13. large donner

    large donner Senior Member (Voting Rights)

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    I'm pretty sure Sharpes SMC hit piece via Reuters made no attempt to show the other side of the argument yet he has the audacity to tell people to tweet his responses to critiques against him.

    Does he tweet out Wilshires papers or Tullers blogs?
     
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  14. Tom Kindlon

    Tom Kindlon Senior Member (Voting Rights)

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