Rethinking childhood adversity in chronic fatigue syndrome (2017) Newton et al.

Cheshire · Nov 27, 2018

James E. Clark, Sean L. Davidson, Laura Maclachlan, Julia L. Newton & Stuart Watson

MEA just published a summary review of this article we previously discussed:

This new study demonstrated that if you remove comorbid depression from the picture, the prevalence of childhood adversity in ME/CFS patients is significantly lower than previously found (17% compared with 66%). Meaning that childhood adversity is more likely to be associated with the development of depression and should not be considered a primary risk factor for ME/CFS
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http://www.meassociation.org.uk/201...childhood-adversity-in-mecfs-30-october-2017/

Reminder: ABSTRACT

Background: Previous studies have consistently shown increased rates of childhood adversity in chronic fatigue syndrome (CFS). However, such aetiopathogenic studies of CFS are potentially confounded by co-morbidity and misdiagnosis particularly with depression.

Purpose: We examined the relationship between rates of childhood adversity using two complimentary approaches (1) a sample of CFS patients who had no lifetime history of depression and (2) a modelling approach.

Methods: Childhood trauma questionnaire (CTQ) administered to a sample of 52 participants with chronic fatigue syndrome and 19 controls who did not meet criteria for a psychiatric disorder (confirmed using the Structured Clinical Interview for DSM-IV). Subsequently, Mediation Analysis (Baye’s Rules) was used to establish the risk childhood adversity poses for CFS with and without depression.

Results: In a cohort of CFS patients with depression comprehensively excluded, CTQ scores were markedly lower than in all previous studies and, in contrast to these previous studies, not increased compared with healthy controls. Post-hoc analysis showed that CTQ scores correlated with the number of depressive symptoms during the lifetime worst period of low mood. The probability of developing CFS given a history of childhood trauma is 4%, a two-fold increased risk compared to the general population. However, much of this risk is mediated by the concomitant development of major depression.

Conclusions: The data suggests that previous studies showing a relationship between childhood adversity and CFS may be attributable to the confounding effects of co-morbid or misdiagnosed depressive disorder.
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https://www.tandfonline.com/doi/abs/10.1080/21641846.2018.1384095?journalCode=rftg20

Squeezy · Oct 30, 2017

"... childhood adversity is far more likely to be associated with major depressive disorder than in the causation of ME/CFS.”

Give the geniuses the Nobel Prize.

Adrian · Oct 30, 2017

There are huge issues with childhood adversary studies that look retrospectively at adversity. It is easy for people to link incidents when told to look back and find reasons for being ill

Squeezy · Oct 31, 2017

Absolutely, @Adrian. If they can't identify a pathogen as the causative agent, then they need to "blame" someone. It's like a witch hunt. Who does it help? Who does it serve?

Are they going to screen people and only let good enough people breed? Can they protect children from bereavement, bullying, illness and accidents?

Are they going to identify children at risk of "Childhood Adversity" and provide early intervention therapy?

NO THEY ARE BLOODY NOT! Because no one will pay for it.

These studies are witch hunts that seek to blame the sufferers of Depression, ME and similar conditions - even though the sufferers are victims of childhood circumstance.

Dolphin · Oct 31, 2017

MEA Summary Review: Rethinking Childhood Adversity in ME/CFS

ME Association

"This new study demonstrated that if you remove comorbid depression from the picture, the prevalence of childhood adversity in ME/CFS patients is significantly lower than previously found (17% compared with 66%).

"Meaning that childhood adversity is more likely to be associated with the development of depression and should not be considered a primary risk factor for ME/CFS."

Visit our website blog to view online or download the full review of this new study.

#MECFS #Research #Newcastle

http://www.meassociation.org.uk/201...childhood-adversity-in-mecfs-30-october-2017/

Cheshire · Nov 8, 2017

Blog post about it (Paul Whiteley):

First, is the whole idea that childhood trauma might be a risk factor for CFS [3]. For those who've followed the ups-and-downs of certain 'biopsychosocial' discussions with CFS in mind (see here), the Clark results represent a bit of a blow to the fluffy psychological thinking that CFS is somehow some kind of 'response' to such adverse events. I'm not saying that childhood adversity can't potentially manifest as a psychiatric disorder (whether contributory in whole or in part) but this latest data perhaps fits with other observations [4] where confounding by "comorbid psychopathology" is to be more typically assumed in the context of CFS. I might also add that CFS is NOT a psychiatric disorder just in case you didn't know...
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https://questioning-answers.blogspo...d-adversity-and-chronic-fatigue-syndrome.html

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Rethinking childhood adversity in chronic fatigue syndrome (2017) Newton et al.

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