Reduced endothelial function in ME/CFS - results from open-label cyclophosphamide intervention study Fluge & Mella 2021

[Marky]

Yep thats what im thinking. Still seems kinda weird to me as i would expext systematic reduced endothelial function to affect functioning level. Im no expert on the values found in the studies compared to healthy values though, but after rituxME and the high amount of placebo im open to the possibility that the reduced endothelial function is in fact causing reduced function, and that the responders are in fact still sick. Just playing devils advocate here

Actually reading over it again i remember that they used sensewear armbands as an objective marker that correlated with scores on questionnaires in the cyclo study.. So i guess placebo is a little less likely, although increases in activity can be due to that to of course.