Processing of Laser-Evoked Potentials in Patients with Chronic Whiplash-Associated Disorders, CFS, and Healthy Controls, 2020, Goudman et al

Discussion in 'ME/CFS research' started by Andy, Apr 15, 2020.

  1. Andy

    Andy Committee Member

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    Paywall, https://academic.oup.com/painmedicine/article-abstract/doi/10.1093/pm/pnaa068/5820105
    Sci hub, https://sci-hub.tw/10.1093/pm/pnaa068

    ETA: Added Sci hub link
     
    Last edited: May 20, 2020
  2. wigglethemouse

    wigglethemouse Senior Member (Voting Rights)

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    Looks like PDF access is free, no paywall, if you click on the PDF symbol

    I'm not able to read in detail, but I took a look at patient selection section. Wouldn't a key part of the investigation of neuropathic pain be to perform traditional diagnostic methods in parallel to confirm a neuropathic biological process? One method could be skin biopsy to look at nerve density that would have confirmed the diagnosis of small fiber neuropathy in patients, who could then undergo the test to confirm the Laser-evoked potentials method can detect a valid change that might indicate CNS fiber issues as well.

    In the end this paper tells us nothing, as we don't know that their pain is neuropathic. Or maybe I need to read the paper and understand what LEP is all about. ;)

    EDIT : I removed my link to the PDF as it times out. Please click on the PDF symbol on the official paper website
     
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  3. rvallee

    rvallee Senior Member (Voting Rights)

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    Seemed like a long shot with a very specific tool.

    https://www.ncbi.nlm.nih.gov/pubmed/14678844
    Unclear how specific and reliable, but it seems only useful to show reduced pain transmission, not increased, which is what was examined here.

    Though considering the objective it's weird they did not include people with fibromyalgia or neuropathy. Weird study.
     
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  4. Dolphin

    Dolphin Senior Member (Voting Rights)

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