Post COVID-19 Syndrome in Patients with Asymptomatic/Mild Form, 2021, Malkova et al

Discussion in 'Long Covid research' started by ola_cohn, Nov 29, 2021.

  1. ola_cohn

    ola_cohn Established Member (Voting Rights)


    Post COVID-19 Syndrome (PCS) is a complex of various symptoms developing a month or more after the acute phase of the disease. The cases of PCS development among patients with asymptomatic/mild forms are frequently reported; however, the pathogenesis of PCS in this group of patients is still not completely clear. The publications about COVID-19 which were published in online databases from December 2019 to September 2021 are analyzed in this review. According to the analysis, PCS develops on average in 30–60% of patients, mainly among women. Fatigue, shortness of breath, cough, and anosmia were reported as the most common symptoms. The possible association between the described PCS symptoms and brain damage was revealed. We assume the possibility of an alternative course of COVID-19, which develops in genetically predisposed individuals with a stronger immune response, in which it predominantly affects the cells of the nervous system, possibly with the presence of an autoimmune component, which might have similarity with chronic fatigue syndrome or autoimmune disautonomia. Thus, the gender (female) and the presence of anosmia during an asymptomatic or mild course of the disease can be predictive factors for the development of PCS, which can be caused by autoimmune damage to neurons, glia, and cerebral vessels.

    Keywords: COVID-19; asymptomatic; mild; Post COVID-19 Syndrome; autoimmune; anosmia; fatigue; Myalgic Encephalomyelitis/Chronic Fatigue Syndrome; autoimmune dysautonomia

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  2. Denise

    Denise Senior Member (Voting Rights)

    Rant -
    In order for me to be able to understand articles about what happens to people after they have acute COVID-19 infections I need to know what they are actually referring to. For me that means appropriate naming of the condition/disease and defining it/them!
    I have seen PASC, LongCOVID, PCS and more. And without uniformity in descriptions I am at a loss to fully understand the discussions!
    alktipping, Trish and Wyva like this.

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