Piezogenic papules in Ehlers-Danlos and ME/CFS?

[Hoopoe]

I saw this on twitter today. To my surprise I have of few these papules on each side.

 

[Andy]

I have of few these papules on each side.

Yeah, me too.

 

[Trish]

Apparently they are very common and usually painless and not a problem.
Most prevalence figures I've seen on a quick search suggest more than half the population have them.

https://www.dermatologyadvisor.com/...genic-pedal-papules-piezogenic-wrist-papules/

The true prevalence is likely in the 75-85% range, consistent with the most recent published data. Painless piezogenic papules should be considered a normal finding or normal variant. They occur in all age groups and in both males and females, although they are reported more often in women than in men.

Cases in the same family have been described, however, given the almost universal prevalence of the condition, it is unlikely that these papules are hereditary. In most cases, painless piezogenic papules are not the result of an inherent connective tissue defect.

 

[Hoopoe]

Many patients on that twitter thread are saying they have these as well. Do we all have EDS or is that just a nonspecific sign?

Edit: Trish was faster.

 

[Trish]

Medscape article here:
https://emedicine.medscape.com/article/1081728-overview#showall

 

[NelliePledge]

Why don’t people check out the general prevalence before including something in criteria it seems such a waste of time.

 

[Jonathan Edwards]

I just checked - yes, I have some nice ones.

I am pretty sure these are entirely normal. (I hope so.)

 

[Jonathan Edwards]

It may be significant that in the Peter Rowe paper that seems to have raised this hare about EDS in the first place piezogenic papules were about the only thing apart from hypermobility that made it look as if the patients had anything specific. If piezogenic papules occur in most of us then that looks pretty unhelpful.