Persistent clotting protein pathology in Long COVID/PASC is accompanied by increased levels of antiplasmin, 2021, Pretorius et al

"
Inflammatory micro clots in blood of individuals suffering from Long COVID
Date:
October 4, 2021
Source:
Stellenbosch University
Summary:
Researchers have found an overload of various inflammatory molecules, 'trapped' inside insoluble microscopic blood clots (micro clots), in the blood of individuals suffering from Long COVID."
https://www.sciencedaily.com/releases/2021/10/211004104134.htm

eta:
Is this what's behind long Covid? Sufferers have 'micro blood clots' that may stop oxygen flowing around the body properly

• 'Long haulers' have a large amount of inflammatory molecules trapped in blood
• These blockages have the potential to disrupt body's ability to distribute oxygen
• It could explain long Covid's most common symptoms, like fatigue & headaches
  
  https://www.dailymail.co.uk/health/...-weeks-beating-illness-micro-blood-clots.html

 

I vaguely remember research that suggested ME could be helped by anticlotting drugs but can't think of the details.

 

Interesting study would like to know if results would also apply to ME

Edit: typo

 

It was a theory from 1999 that pwME and now pwLyme and MCAS (add on more) were/are in a hypercoagulative (thick blood) state where injecting heparin dissolves fibrin.

So the theory goes that a hypercoagulable state starves cells of oxygen and nutrients.

 

@Adam pwme posted video clip of Dr Asad Khan BBC interview on Apheresis and microclots.

(Apologies not a good day but I have some questions)

Am I posting a relevant/best thread?
Is venous oxygen saturation testing he mentioned easy to do. Any ME studies use this measure?
This is H.E.L.P Apheresis? Only available Germany?
What is the assessment/opinion of the level of effective collaboration in any direction MECFS-LC?

 

Also interesting from the BBC clip of dr Assad Khan was that the clots were not picked up by tests such as fibrin and d-dimer.

 

I think it needs a venous catheter? I remember a relative having one during his treatment. It's presumably fairly routine in hospitals when monitoring some conditions, but it's invasive, so I doubt it's something a local clinic would offer.

 

https://www.youtube.com/watch?v=I27BNejDJpI

I would be very interested to hear views on this from more people who understand the science – particularly with regard to whether it could apply to people with ME.

 

Edit - removed unnecessary section (brain fail)

In the clip above of Dr Khan on BBC news he says that “a simple bedside test called a venous oxygen saturation can demonstrate how ill we are”

For those like me who don’t know what that is: https://www.ncbi.nlm.nih.gov/books/NBK564395/

 

On Twitter the main author of this study said they are working on a ME/CFS study:

https://twitter.com/user/status/1451584595992977408


https://twitter.com/user/status/1451606225070788640

 

This may be of interest. Comment posted on the YouTube video. Link to the paper below.

https://pubmed.ncbi.nlm.nih.gov/10695770/

 

https://www.resiapretorius.net/

Website of professor quoted above as planning an MECFS study.

Collaborated with Beate Jaeger on H.E.L.P Apheresis.

 

You know those air fresheners in public buildings that are triggered by opening the door to the toilets?

Every time the door of the staffroom is opened in one of the fatigue clinics, it should trigger a recording of Dr Khan's "It is a myth" statement.

 

These tests were done through David Berg HEMEX labs. I had this test done and so did many others w ME/CFS back in the late nineties. None of us had antiphospholipid antibody syndrome. None.

 

Isn't apheresis a treatment that you have to have repeatedly?

 

This looks interesting. I remember reading years ago about a patient with ME/CFS who figured out he really had some sort of clotting problem. It would not be surprising if this was a subset of ME/CFS, now also appearing in long covid (perhaps more prominently due to specific effects of the SARS-2 virus).

 

They're saying 'a version of APS syndrome', which I suppose could mean something that is not APS but produces similar effects? It's not a very satisfactory way of expressing it, though, even assuming they know what they mean in the first place.

 

@Kitty

I also had an ISAC (Immune System Activation of Coagulation) panel done which is most likely a 'version' of APS.

This is recycling pet theories all over again.

 

If you can't remove the cause of the sticky blood, then I guess yes? But if it actually worked, it would provide a target for further research. And once a lot of the gunk has been filtered out, treatment with existing drugs might help delay its return.