Mentioned in this thread Differentiating post-polio syndrome from myalgic encephalomyelitis and chronic fatigue syndrome, 2019, Jason et al Richard L. Bruno, HD, PhD, et al. American Journal of Medicine,1998, 105 (3A): 66-73. https://www.papolionetwork.org/uplo...en_post-polio_fatigue_and_chronic_fatigue.pdf Abstract Fatigue is the most commonly reported and most debilitating Post-Polio Sequelae (PPS) affecting the more than 10 million worldwide polio survivors. Post-polio fatigue is characterized by subjective reports of difficulty with attention, cognition and maintaining wakefulness, symptoms reminiscent of nearly two dozen outbreaks during this century of post-viral fatigue syndromes (PVFS) that are related clinically, historically, anatomically or physiologically to poliovirus infections. Recent studies that relate the symptoms of post-polio fatigue and Chronic Fatigue Syndrome (CFS) to clinically significant deficits on neuropsychological tests of attention, histopathologic and neuroradiologic evidence of brain lesions, impaired activation of the hypothalamic-pituitary-adrenal axis, increased prolactin secretion and EEG slow wave activity are reviewed. Described will be a possible common pathophysiology for post-polio fatigue and CFS, based on the Brain Fatigue Generator Model of PVFS, and a possibility pharmacotherapy for PVFS based on the replacement of brain dopamine.