Ozempic, tirzepatide and other GLP-1RAs - impact on ME/CFS

I am trialling Mounjaro since around 6 or 7 weeks. BMI now 19.5. since beginning lost around 2-3 kg (the LDA weight gain). Will update in a few weeks.
 
Jaybee00 said:
Why are you taking it if your BMI is 19???
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I try it for ME. It is supposed to lower inflammation and is being studied for condition like ours. I experiment a lot, yes - my condition is dire and I need anything which could make me even 10% better. I am not sensitive to medication - never have side effects, but also rarely effects.

Of course I take it low dose (am titrating up to 2.5 mg from 1 mg)
 
I have been on mounjaro for 16 months. Weight loss 21% of body weight. I have lipolymphadema so this is considered " have done very well " according to lymphology Consultant because lipoedema fat doesn't respond to GLP1s.

No effect at all on ME/CFS.
 
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Article in Psychology Today:

When their appetite is severely suppressed, people tend to eat whatever sounds tolerable rather than what's nutritionally optimal. This can lead to inadequate protein and micronutrient intake.

Malnutrition Is Common​

A study examining over 460,000 patients who were prescribed GLP-1 agonists found that 22% developed nutritional deficiencies within 12 months of starting treatment. Vitamin D deficiency was the most common, affecting 13% of patients within one year. But the deficiencies went far beyond a single vitamin—vitamin A, vitamin C, B vitamins, calcium, and zinc levels were also reduced.


Physical symptoms of these nutritional deficiencies can include hair loss, fatigue, muscle weakness, and slow wound healing. As a psychiatrist, I recognize that these same deficiencies can also cause psychiatric symptoms like depression, anxiety, and cognitive impairment. All of these problems can originate from insufficient vitamins and minerals.
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22% of 460,000 patients prescribed GLP-1 drugs developing nutritional deficiencies? That sounds unlikely to me. Unless maybe doctors are taking the risk of nutritional deficiencies when taking these drugs seriously and are testing and finding issues like Vitamin D deficiency that were there before the drug was started.

But, I can see nutritional deficiencies being something people with ME/CFS on these drugs need to watch out for. It's hard to prepare a balanced nutritious meal when you don't have energy, even more so if you live on your own and don't have a good income, as is the case for so many of us. If people aren't getting outside in the sun much, then the nutritional sources of Vitamin D become important.

And the symptoms of nutritional deficiencies sound to overlap with some ME/CFS symptoms, so it could be hard to identify early signs of deficiencies. I heard a dietician on the radio talking about this and recommending that people losing weight should take a multivitamin as an insurance against inadequate intake.
 
Sid said:
That's amazing, congrats! The % loss is exactly what you'd expect based on the average outcome in clinical trials of tirz.
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Thank you @Sid.
I am pretty pleased especially because of having lipoedema. That hasn't moved at all and seems more obvious because of the loss of the adipose fat. One odd thing is that I actually reached this weight a couple of months ago then the loss stopped dead; there has been no more loss even though I have not changed the dosage of tirz. I'm not sure if something metabolic happened around then or if subconsciously, I stopped working on the diet part of the process and have been less rigorous in my eating.
 
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