Multidimensional studies Myalgic Encephalomyelitis/Chronic Fatigue Syndrome at the National Institutes of Health Lead researcher: Avindra Nath National Institute of Neurological Disorders and Stroke (NINDS) Study Start Date: January 21, 2016 Estimated Study Completion Date: September 15, 2020 More information Dr Avindra Nath presenting the study (video) ME/CFS Severely ill Big Data Study Open Medicine Foundation More information NIH ME/CFS centers: (S4ME thread) *Cornell ME/CFS Collaborative Research Center Lead researcher: Maureen Hanson, Ph.D. Cornell University, Ithaca, New York Center registration More information Main research projects: - Brain imaging study, led by Dikoma Shungu (See the neurology studies list below for more information) - Extracellular vesicles, led by Hanson (See the immunology studies list below for more information) - RNAs in white blood cells, led by Andrew Grimson (See the genetic studies list below for more information) * Center for Solutions for ME/CFS Lead researcher: W. Ian Lipkin, M.D. Columbia University, New York City Center registration More Information *Topological Mapping of Immune, Metabolomic and Clinical Phenotypes to Reveal ME/CFS Disease Mechanisms Lead researcher: Derya Unutmaz, M.D. The Jackson Laboratory, Farmington, Connecticut Center registration More Information *Data Management and Coordinating Center (DMCC) for the ME/CFS Collaborative Research Centers Lead researcher: Rick L. Williams, Ph.D. Research Triangle Institute, Research Triangle, North Carolina Center registration ME/CFS Collaborative Research Center at Stanford Lead researcher: Ronald W. Davis Research projects: T cells and the molecular immunology of ME/CFS Extended big data study in families Developing blood-based diagnostic and drug screening technology More information S4ME thread Immunology Immune System Dysfunction Lead researchers: Professor Stephen Todryk and Professor Julia Newton ME Association Ramsay Research Fund / Action for ME Start: 2014 More information Cyclophosphamide in Myalgic Encephalopathy/ Chronic Fatigue Syndrome (ME/CFS) (CycloME) Treatment study Lead researchers: Mella Olav, Øystein Fluge Haukeland University Hospital Start: 2015 Estimated Study Completion Date: January 2017 More information The role of autoantibodies in ME/CFS Lead researchers: Dr Madlen Löbel & Prof. Carmen Scheibenbogen Institute of Medical Immunology, Charité University Medicine Berlin, Berlin, Germany MERUK More Information An immunosignature assay for rituximab therapy? Lead researcher: Prof. David Patrick School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, USA MERUK More information Lymphocyte phenotype and cytokine production in ME/CFS patients and patients treated with chemotherapy for breast cancer Lead researchers: Dr Clive Carter, Dr Philip Wood and colleagues Leeds NHS Teaching Hospital NHS Trust, St James’s University Hospital, Leeds MERUK More information Ampligen in Chronic Fatigue Syndrome Treatment study Hemispherx Study Start Date: March 1997 Estimated Study Completion Date: February 2019 More information S4ME thread Extracellular vesicles Lead researcher: Maureen Hanson Cornell Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Collaborative Research Center More Information Combatting oxidative stress Lead researchers: Dr Faisel Khan, Prof JD Hayes, Prof J Belch, et al. Vascular & Inflammatory Diseases Research Unit, Division of Cardiovascular & Diabetes Medicine and Division of Cancer Research, Ninewells Hospital & Medical School, Dundee, UK MERUK More information Immunoadsorption in patients with autoantibodies to ß adrenergic receptors Treatment study Lead researcher: Carmen Scheibenbogen Charité, Berlin, Germany Fresenius Medical Care More information (German) HyQvia in patients with immunoglobulin deficiency, frequent infections and CFS Treatment study Charité, Berlin, Germany Baxalta More information (German) Information on HyQvia Chronic fatigue syndrome: Leptin, interleukin 6 and clinical symptoms Lead researcher: Michael Musker South Australian Health And Medical Research Institute (SAHMRI), Australia More information Immuno-senescence and cell-cycle analysis in the pathophysiology of ME/CFS Lead researchers: Dr. Sheila Stewart, Dr. Masashi Narita Washington University (USA), Cambridge University (UK) SMCI More information Biomarkers for initiation (infection) and metabolic derangement in ME/CFS Lead researchers: Drs. Blomberg, Bergquist, Gottfries, and Zachrisson Gottfries clinic, Mölndal, Uppsala University Hospital (Sweden) SMCI, Ramsay Award Program (2017) Start: 2018 More information Immunometabolism of T cells and monocytes in ME/CFS Lead researchers: Drs. Carmen Scheibenbogen and Franziska Sotzny Charité – Universitätsmedizin Berlin (Germany) SMCI, Ramsay Award Program (2017) Start: 2018 More information Metabolic Analysis of B Cell Maturation Lead researchers: Chris Armstrong, Fane Mensah and Professor Jo Cambridge Melbourne Bioanalytics (Australia), University College London (UK) SMCI, Ramsay Award Program (2016) More information SMCI presentation Metabolic Assessment of Natural Killer Cells Lead researchers: Drs. Isabel Barao-Silvestre, Ruben Dagda, and Victor Darley-Usmar University of Nevada Reno, University of Alabama, Birmingham (USA) SMCI, Ramsay Award Program (2016) More information Identifying Autoimmune signatures in ME/CFS Lead researchers: Dr. Carmen Scheibenbogen and Madlen Lobel Charité University Medicine Berlin, Charité Universitatsmedizin Berlin (Germany) SMCI, Ramsay Award Program (2016) More information The potential role of HHV-6 in ME/CFS Lead researcher: Bhupesh Prusty Julius Maximilian University of Wurzburg (Germany) SMCI, Ramsay Award Program (2016) More information Investigation of human endogenous retrovirus expression in individuals with myalgic encephalomyelitis Lead researcher: Dr Camila Malto Romano USP - Universidade de São Paulo (Brazil) Using UK ME CFS Biobank More information Droplet digital PCR for evaluation of associations between human Herpes virus infection and Myalgic encephalomyelitis/chronic fatigue syndrome(ME/CFS) Lead researchers: Eleanor Riley, Jackie Cliff London Sch/Hygiene & Tropical Medicine More information A longitudinal immunological and virological study for ME CFS biomarker discovery Lead researcher: Luis Nacul London Sch/Hygiene & Tropical Medicine More information Defining autoimmune aspects of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) PhD research: Katharine Seton Invest in ME More information Energy metabolism Examining Mitochondria in ME/CFS Lead researcher: Dr Karl Morten ME Association Ramsay Research Fund Using UK Biobank samples Start: 2017 More information S4ME thread Comparison of results from a commercial and NHS blood test to assess mitochondrial function Lead researcher: Dr Sarah Jayne Boulton ME Association Ramsay Research Fund More information Abnormalities in Mitochondrial Function in Skeletal Muscle Lead researcher: Professor Anne McArdle ME Association Ramsay Research Fund/Medical Research Council Preliminary results (2015) More information Bioenergetics capacity, ATP production and potential drug targets using advanced technologies Lead researcher: Dr. Ralph Garippa Memorial Sloan Kettering Cancer Center (MSKCC), New York City (USA) SMCI More information Projects Longitudinal metabolic and genomic study Lead researcher: Chris Armstrong Melbourne Bioanalytics, Australia More information Mitochondrial Respiratory Function and Cellular Metabolism in Lymphoblasts Lead researcher: Chris Armstrong, Daniel Missailidis and Paul Fisher Melbourne Bioanalytics, LaTrobe University, Australia More information Muscles studies Investigating abnormalities in AMPK activation Lead researcher: Dr Audrey Brown Institute of Cellular Medicine, Newcastle University, Newcastle, UK MERUK More information Muscle metabolites in patients before and after exercise Lead researchers: Pr. Kevin Conley, Pr. David Maughan University of Washington SMCI, Cathleen J. Gleeson PhD Fund More information Neurology studies Neurological biomarkers in paediatric ME/CFS Lead researcher: Dr Sarah Knight and colleagues Murdoch Children’s Research Institute, The Royal Children’s Hospital, University of Melbourne, Melbourne, Australia MERUK More information Markers of neuroinflammation and oxidative stress Lead researcher: Dikoma Shungu Cornell Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Collaborative Research Center More information Interrogating the brain: experiments with laser-evoked potentials and cerebral blood flow Lead researchers: Prof. J. Nijs, Prof P. Cras, Prof F. visser, M. de Kooning and colleagues Faculty of Physical Education and Physiotherapy, Vrije Universiteit Brussel, Brussels, Belgium MERUK More information Development of surrogate end-point biomarkers for chronic fatigue and myalgic encephalmyelitis/chronic fatigue syndrome (ME/CFS) Lead researcher: Watanabe Pet Scan study Japan More Information S4ME thread Exploring Brain Inflammation Lead researcher: Dr. Jarred Younger University of Alabama, Birmingham (USA) SMCI, Ramsay Award Program (2016) More information Projects Glial activation in brainstem Dr. Michael VanElzakker Massachusetts General Hospital More information S4ME thread Autonomic system ME/CFS: Activity Patterns and Autonomic Dysfunction Lead researcher: Fred Friedberg Stony Brook University New York, United States NIH funds Study Start Date: June 2016 Estimated Study Completion Date: May 2020 More information S4ME Thread If you have questions or want to make a suggestion, please go to the Librairy Discussions thread.