OMF: A Holiday message from Dr. Ron Davis, 2018

A Holiday message from Dr. Ron Davis, 2018

https://www.youtube.com/watch?v=VScir4Dfk58

 

So does this mean that all the information they thought they had on metabolic trap is questionable or wrong? I'm not sure how to interpret what Dr.Davis said?

 

Sounds like the metabolic trap is back to being an untested hypothesis.

 

Any thoughts @alex3619 or @JaimeS ?

 

Towards the end of his presentation at the recent OMF symposium Phair said that they'd already started testing the hypothesis and showed the early results having tested 6 patients with ME/CFS (and he intimated that this testing used a mass spectrometer). I think we have to assume that the results he showed (the three graphs that appeared to support his testable predictions about cellular tryptophan and kyneurenine and the kyn/trp ratio) aren't reliable - at least until we hear more from the OMF.

 

One thing I have noticed about Ron Davis’s OMF work is if there is no way to test what he wants to test, he will attempt to try to develop a test. I suspect that’s a difference from having private funding rather than government funding. He has the leeway to do this.

 

I wonder if it's variability in the sample or variability in the instrument; I assume that it's variability in the instrument. E.g. test same patient multiple times and the results vary (e.g. you can't reliably extract the PBMCs/extract tryptophan from PBMCs) or test the same sample multiple times and the results vary (e.g. instrument - mass spectrometer variability).

We need public i.e. government funding;most significant science breakthroughs have their origin in publicly funded research. The gulf war veterans are getting some funding but ME/CFS is getting very little. The big pharmaceutical firms may come on board at some point but until then we need public funding.

 

I think OMF needs advice from a communication specialist. It should be considered as an investment .

 

Why so?